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Director, Clinical Pharmacology

Crescent Biopharma
Waltham, MA Full Time
POSTED ON 6/3/2026
AVAILABLE BEFORE 8/3/2026
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Responsibilities
  • Serve as the lead clinical pharmacologist on the project team, accountable for clinical pharmacology deliverables, providing subject matter expertise on PK/PD and quantitative pharmacology.
  • Play a pivotal role in planning and executing clinical pharmacology activities to support development programs.
  • Drive utilization of model-based drug development approach for human PK prediction, dose and dosing regimen selection and optimization, collaborating closely with cross functional colleagues.
  • Oversee and/or perform PK/PD data analyses and contribute to the interpretation of study results through all phases of clinical development.
  • Lead preparation and review of clinical pharmacology sections of study protocols, reports, investigators' brochures and regulatory filings (IND’s, BLA’s, etc.), and respond to regulatory inquiries related to clinical pharmacology.
  • Provide oversight to vendors and consultants to ensure timely delivery of high-quality data and reports to support go/no-go decisions and dosing strategy.
  • Assure the implementation and adherence to SOPs, GXPs, and regulatory standards in clinical pharmacology programs.


Education & Experience
  • PhD in pharmaceutical sciences, pharmacology with a focus on pharmacokinetics and pharmacometrics.
  • Strong understanding of clinical pharmacology study design, data analysis, and regulatory requirements.
  • Minimum 8 years of experience in clinical pharmacology and pharmacometrics, with hands-on experience in PK data analysis.
  • Prior experience in the field of ADC development is a plus.
  • Experience in the Oncology therapeutic area is highly desirable.


What We Offer
  • Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment
  • Competitive compensation, including base salary, performance bonus, and equity
  • 100% employer-paid benefits package
  • Flexible PTO; also, two, one-week company-wide shutdowns each year
  • A commitment to your professional development, with access to resources, mentorship, and growth opportunities
 
#LI-CBIO


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$226,000 - $250,000 a year
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Salary : $226,000 - $250,000

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