Senior Bioinformatics Analyst

At Cincinnati Children’s Hospital Medical Center - consistently recognized as one of the nation’s top places to work and a global leader in pediatric research and care - we are driven by a shared commitment to discovery, collaboration, and impact. We are seeking a highly motivated Bioinformatics Analyst or a Postdoctoral Research Fellow at various career stages. Exact position and title will be commensurate with the candidate’s qualifications and experience. The Computational Regulatory Genomics Laboratory develops statistical and machine learning–based methods to understand the fundamental mechanisms of gene transcriptional regulations in various biological contexts. Our research focuses on enhancer regulation and systems-level understanding of enhancer architectures and functions across diverse biological contexts. We integrate multi-omics data, including ChIP-seq, ChIP-exo, CUT&RUN, GRO-seq, csRNA-seq, RNA-seq, ATAC-seq, Hi-C, and single-cell technologies, to delineate heterogeneous architectures of transcription factor binding events and chromatin landscapes at high resolution. The lab broadly collaborates with multiple experimental laboratories, encompassing metabolism, cancer, and development. The lab’s works were published in many high-profile journals such as Nature, Cell Metabolism, Molecular Cell, Genes & Development, Circulation, Nature Communications, and the Journal of Clinical Investigation. JOB RESPONSIBILITIES Informatics Curates, annotates and organizes various types of biomedical data (e.g., genomic, clinical, imaging, sequencing) in various formats (e.g., flat files, relational and non-relational databases). Collects and records appropriate metadata. Ensures data are securely stored yet highly accessible to authorized users. Develops and executes data characterization/quality assessment routines of basic to moderate complexity including metadata standardization. Data Analysis Assists analysts and managers in building robust pipelines for curating, processing and analyzing biomedical data of various types (e.g., genomic, clinical, imaging, sequencing). Utilizes existing software and contributes to the development of new and existing tools to support complex data management tasks (e.g., sequence alignment, variant calling, inter-sample comparison, patient matching/linkage). Helps develop scalable, searchable and secure data structures, utilizing best-practices as much as possible. Incorporates institutional resources and 3rd party software into specialized analysis workflows for the team and clients. Maintains computational infrastructures and controls the flow of data and information for studies. Provides web-based bioinformatics tools and access to public and proprietary relational databases. Documents standard operating procedures based on best practice. Works in collaboration with both technology and scientific teams. Requirements Gathering Interfaces with clinicians/researchers to collect requirements of basic to moderate complexity including user workflows. Problem-solves and discusses possible solutions with the stakeholders. Considers the implications of possible solutions on the current environment. Software Evaluation & Development Contributes to the evaluation and development of software solutions to support basic to moderately complex data workflows. Participates in various aspects of the software development life cycle, including identification of key stakeholders, design requirements gathering, system analysis and design, code generation, testing and implementation. Effectively communicates the status of all efforts to necessary parties. Utilizes project and time management skills to complete projects within specific timeframes. Publication Contributes to analyses and publications. Generates reports and figures for publications. Assists with materials for publications and scientific meetings. Works closely with biostaticians on the production of publication and presentation materials. JOB QUALIFICATIONS Bioinformatics Analyst: Master's or doctoral degree in a related field 2 years of work experience in a related job discipline OR equivalent combination of education and experience Research Fellow: Doctoral degree in a related field 4 years of work experience in a related job discipline OR equivalent combination of education and experience Primary Location Exploration Avenue Schedule Full time Shift Day (United States of America) Department Biomedical Informatics Employee Status Regular FTE 1 Weekly Hours 40 About Us At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.  Cincinnati Children's is: Recognized by U.S. News & World Report as a top 10  best Children's Hospitals in the nation for more than 15 years Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH) Funding Recognized as one of America’s Best Large Employers  (2025), America’s Best Employers for New Grads (2025) One of the nation's America’s Most Innovative Companies as noted by Fortune Consistently certified as great place to work A Leading Disability Employer as noted by the National Organization on Disability Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)  We Embrace Innovation—Together. We believe in empowering our teams with the tools that help us work smarter and care better. That’s why we support the responsible use of artificial intelligence. By encouraging innovation, we’re creating space for new ideas, better outcomes, and a stronger future—for all of us. Comprehensive job description provided upon request. Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability Completion of Application You will be asked to fully complete each page of the application to the best of your knowledge. Failure to complete all parts of the application will result in a delay in processing and/or rejection of the application. Need Assistance or Accommodation? Assistance with Application: For assistance or technical support, email applicationassistance@cchmc.org. Accommodation: We provide reasonable accommodations to qualified individuals with disabilities in accordance with the Americans with Disabilities Act and applicable state and local law. If you require an accommodation in the application process, email applicationassistance@cchmc.org.