Scientist II, In Vitro Pharmacology

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

AbbVie is seeking a driven and innovative Scientist II, In Vitro Pharmacology, to join the mRNA-tLNP group. The Scientist II, In Vitro Pharmacology, will develop and perform cell-based assays to generate data that advance mRNA-tLNP pipeline programs from early discovery through IND-enabling studies, with an emphasis on applications in oncology and autoimmune diseases.

Responsibilities

• Lead the design, optimization, and execution of in vitro assays to evaluate mRNA-tLNP-mediated T-cell reprogramming, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.
• Develop and deliver high-quality in vitro data packages to drive progression of the in vivo mRNA-tLNP pipeline programs, proactively leveraging cross-functional expertise by collaborating closely with research, bioinformatics, translational, and project management teams.
• Actively pursue mastery of innovative experimental techniques and emerging scientific tools to enhance scientific rigor, while serving as a subject matter resource and mentor to teammates, fostering a culture of continuous learning and knowledge sharing within the group.
• Exhibit and maintain a high level of technical proficiency and scientific acumen within the field of in vitro pharmacology, demonstrating expertise in experimental design, data interpretation, and troubleshooting.
• Independently establish, monitor, and deliver on project milestones and experimental timelines, ensuring alignment with program goals and organizational priorities, while maintaining flexibility to adapt to evolving scientific needs.
• Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports.
• Make substantive contributions to scientific publications, patent applications, and conference presentations by providing conceptual input, technical writing, data analysis, and critical review, in alignment with AbbVie's standards of scientific excellence and innovation.
  
  
  

Qualifications

• BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience, in immunology, cell and molecular biology or related field.
• Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions. Proven capacity to quickly learn and apply new laboratory techniques. Able to manage multiple tasks efficiently while meeting deadlines. Strong skills in scientific writing and verbal communication.
• Previous experience in chimeric antigen receptor (CAR) production and evaluation is desirable.
• Deep expertise in primary human T-cell biology, including isolation, activation, and specialized expansion protocols, cytotoxicity, proliferation and cytokine profiling.
• Mastery of high-parameter flow cytometry (panel design and data deconvolution) and molecular techniques such as ddPCR or RT-qPCR.
• Experience with scientific data analysis software including CellEngine and Tableau is desirable.
  
  
  

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our short-term incentiveprograms.
  
  
  

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's soleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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