Associate Scientist II, In Vitro Pharmacology

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

Job Description

AbbVie is seeking a driven and innovative Associate Scientist II, In Vitro Pharmacology, to join the mRNA-tLNP group. The Associate Scientist II, In Vitro Pharmacology, will develop and perform cell-based assays to generate data that advance mRNA-tLNP pipeline programs from early discovery through IND-enabling studies, with an emphasis on applications in oncology and autoimmune diseases.

Responsibilities

• Execution in vitro assays to evaluate mRNA-tLNP-mediated T-cell reprogramming, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.
• Isolate PBMCs and T cells from leukopaks.
• Use aseptic techniques to culture mammalian cells, including tumor cell lines, T cells, and PBMCs.
• Make stable tumor cell lines using techniques such as electroporation, viral delivery, and nanoparticle transfections.
• Perform routine tasks competently and independently, and generate reliable and consistent results.
• Demonstrate skill in multiple techniques and appropriately modify protocols, as required, to suit the changing needs of research or development sciences.
• Maintain and implement good laboratory practice including an accurate online laboratory notebook system, instrument and reagent validation, and personal safety precautions.
• Work collaboratively in a cross-functional team environment. Organize and communicate data (written and oral) and participate in project team meetings.
  
  
  

Qualifications

• Bachelors Degree, or equivalent education, with typically 3 or more years experience or Masters Degree or equivalent education (no additional experience), in immunology, cell and molecular biology or related field.
• Previous experience in chimeric antigen receptor (CAR) production and evaluation is desirable.
• Experience with aseptic/sterile techniques culturing of mammalian cells, including cell lines, T cells, and PBMCs.
• Experience with viral and non-viral gene transfer techniques to engineer mammalian cells.
• Experience designing and executing assays to assess T cell function including cytotoxicity, activation, proliferation and cytokine profiling.
• Proficiency in flow cytometry and data processing.
• Experience designing and executing plate-based assays, including ELISA and Luminex/MSD.
• Experience with scientific data analysis software including CellEngine and Tableau is highly preferred.
• Experience with digital PCR is desirable.
  
  
  

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentiveprograms.
  
  
  

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's soleandabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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