Principal Scientist or Director

Principal Scientist or Director

Direct Hire Full-Time Role

Salary Range: $120,000 - $140,000 per year

Location: Irvine, CA - Onsite Role

Job Summary:

We are seeking a highly motivated, passionate, and detail-oriented Principal Scientist to join our Antibody Therapeutics team. This is an exciting opportunity to contribute to a fast-growing, AI-driven biotherapeutics company dedicated to rapidly generating next-generation biologics for Immunology & Inflammation (I&I) and metabolic diseases.

Duties and Responsibilities:

• Lead the design, discovery, and optimization of monoclonal, bispecific, and multispecific antibodies using display and screening platforms (B-cell cloning, phage, and yeast display).
• Perform high-throughput antibody screening assays, including binding kinetics, ligand blocking, and epitope binning, to rapidly identify and prioritize lead candidates.
• Design and develop recombinant protein-based immunoassays to characterize therapeutic antibodies using biochemical and biophysical methods.
• Execute small- and large-scale antibody expression and purification using chromatography techniques and evaluate purity via SDS-PAGE, analytical SEC, and Western blot.
• Co-lead biotherapeutic discovery campaigns and partner closely with in vitro and in vivo pharmacology teams to evaluate PK/PD, efficacy, and safety profiles.
• Provide strategic and technical input on antibody design, developability, and candidate selection during early-stage development.
• Interface with CROs and external collaborators to ensure high-quality data generation and timely project execution.
• Present experimental results and program updates to project teams, senior management, and collaborators.
• Maintain accurate experimental documentation in ELN and ensure compliance with best data practices.
• Stay current with emerging literature and technologies relevant to antibody engineering and biologics discovery.

Requirements and Qualifications:

• PhD in Biochemistry, Biomedical Engineering, Molecular Biology, Immunology, or related discipline with at least 7 years (Principal Scientist) or 10 years (Director) of research experience working in a biotech or large pharma setting is a must.
• Experience with antibody pipeline discovery, screening, antibody engineering, and optimization in the field of I&I or metabolic diseases is a must.
• Expertise in designing and conducting in vitro protein-based assays using diverse biophysical and bioanalytical methods (e.g., SPR/BLI, ELISA, DLS, thermal stability, immunoassays) is a must.
• A strong understanding of protein engineering, Fc modifications, and developability assessments is essential.
• Ability to work independently and as part of a team in a fast-paced environment, with strong analytical and problem-solving skills, and attention to detail is essential.
• Experience with antibody screening databases and proficiency in data analysis/visualization software, such as Spotfire, Dotmatics, D360, etc., is a plus.
• Demonstrated scientific innovation and productivity, as evidenced by patents and/or peer-reviewed publications.
• Strong communication and interpersonal skills, with the ability to present complex data clearly to cross-functional teams, leadership, and collaborators.
• Self-motivated, collaborative, and enthusiastic about contributing to a multidisciplinary, early-stage biotech focused on breakthrough antibody therapeutics.

Desired Skills and Experience

Antibody discovery and engineering, monoclonal bispecific and multispecific antibodies, antibody optimization and developability assessment, display technologies (B-cell cloning, phage display, yeast display), high-throughput antibody screening, binding kinetics analysis, ligand blocking assays, epitope binning, recombinant protein expression and purification, chromatography techniques, SDS-PAGE, analytical SEC, Western blotting, protein biochemistry and biophysics, immunoassay development, SPR and BLI, ELISA, DLS, thermal stability analysis, Fc engineering and modifications, biotherapeutic discovery leadership, PK/PD evaluation, in vitro and in vivo pharmacology collaboration, efficacy and safety assessment, early-stage biologics development, CRO and external partner management, project and program leadership, data analysis and visualization (Spotfire, Dotmatics, D360), antibody screening databases, experimental design and documentation, electronic lab notebooks (ELN), scientific communication and presentations, cross-functional collaboration, immunology and inflammation therapeutics, metabolic disease therapeutics, AI-enabled biologics discovery, biotech and pharma research experience, patents and peer-reviewed publications

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