Summer Intern, Antibody Discovery

Arrowhead Pharmaceuticals, Inc. (Nasdaq{{:}}  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

The Antibody Discovery Summer Intern will support Discovery Chemistry research at Arrowhead Pharmaceuticals’ Madison, WI site, contributing to projects focused on antibody development and screening to advance RNAi therapeutic delivery. This internship offers hands-on laboratory experience in molecular biology, biochemistry, and cell biology while working alongside scientists on research that directly supports in vivo study prioritization. The intern will gain practical exposure to antibody engineering, screening strategies, and collaborative research in a pharmaceutical discovery environment.

This is an 11-week Summer Internship Program paying $21.00 per hour and requires full-time, onsite work five days per week at the designated location.

Responsibilities

• Culture mammalian cells to produce and test proteins.
• Clone DNA constructs to support protein and antibody expression.
• Express and purify novel antibody constructs.
• Screen novel biologics and oligonucleotides for in vitro activity.
• Investigate cell binding, internalization, and trafficking of antibodies and receptors.
• Maintain accurate and well-organized experimental records.
• Collaborate effectively within a cross-functional research team.
• Follow established laboratory procedures, safety guidelines, and quality standards
• Present project updates in weekly group meetings.
• Prepare final deliverables, including a scientific poster and a ~20-minute presentation summarizing project objectives, results, and learning.

Requirements

• Currently enrolled student at an accredited university or college with 2–3 years of college-level coursework in Biochemistry, Biology, or a related scientific discipline.
• Excellent verbal and written communication skills, including comfort presenting in group settings.
• Strong problem-solving and organizational skills.
• Proficiency in Microsoft Office applications.
• Ability to lift up to 40 lbs.
• Willingness and ability to spend 75% of the workday in laboratory environments and 25% at a desk

Preferred

• Completion of coursework in Organic Chemistry, Biochemistry, Molecular Biology, and Immunology.
• Prior laboratory experience, including molecular biology or cell-based assays.
• Strong interest in antibody engineering, biologics, or drug discovery research

Wisconsin pay range {{:}} $9,240 USD - $9,240 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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