What are the responsibilities and job description for the Senior AI Protein Engineer position at AllSTEM Connections?
A well-funded, interdisciplinary medical research institute in Los Angeles is seeking a Senior AI Protein Design Engineer to spearhead a new initiative in de novo therapeutic engineering. This is a foundational role where you will build the computational architecture for next-generation peptide and protein discovery from the ground up.
You will work at the intersection of machine learning and structural biology, translating high-level computational designs into experimental reality through close collaboration with our in-house wet-lab and translational research teams.
Core Responsibilities:
- Pipeline Architecture: Develop and deploy robust computational pipelines for de novo protein and peptide design, utilizing state-of-the-art generative models.
- Lead Optimization: Leverage sequence- and structure-based modeling to predict stability, folding, and binding properties for therapeutic leads.
- Design-Build-Test: Drive iterative cycles by interpreting experimental data from production teams to refine and improve AI model performance.
- Technical Leadership: Shape the technical roadmap for the group's AI capabilities and mentor junior computational scientists.
Required Qualifications:
- Ph.D. in Computational Protein Design, Structural Biology, Bioinformatics, or a related field.
- 5 years of hands-on experience in macromolecular modeling and sequence/structure prediction.
-Technical Proficiency: Expert-level experience with modern tools such as AlphaFold, RoseTTAFold, RFdiffusion, or ProteinMPNN.
- Collaborative Track Record: Proven ability to work alongside experimental biologists and translate "in silico" results into actionable "in vitro" benchmarks.
- Therapeutic Insight: A strong understanding of protein folding, stability, and the constraints of drug development. Equal Opportunity Employer / Disabled / Protected Veterans
The Know Your Rights poster is available here:
_EEOC_KnowYourRights6.12.pdf
The pay transparency policy is available here:
_ English_formattedESQA508c.pdf
For temporary assignments lasting 13 weeks or longer, AllSTEM Connections is pleased to offer major medical, dental, vision, 401k and any statutory sick pay where required.
We are committed to working with and providing reasonable accommodations to individuals with disabilities. If you need a reasonable accommodation for any part of the employment process, please contact your staffing representative who will reach out to our HR team.
AllSTEM Connections participates in the E-Verify program in certain locations as required by law. Learn more about the E-Verify program.
_Participation_Poster_ES.pdf
We also consider for employment qualified applicants regardless of criminal histories, consistent with legal requirements, including, if applicable, the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance. Pursuant to applicable state and municipal Fair Chance Laws and Ordinances, we will consider for employment-qualified applicants with arrest and conviction records, including, if applicable, the San Francisco Fair Chance Ordinance. For Los Angeles, CA applicants: Qualified applications with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act.
Additional Skills
(none specified)
AllSTEM Representative Contact Info
Account Executive:
Giampaolo
Branch Phone:
Location:
Ontario, CA
You will work at the intersection of machine learning and structural biology, translating high-level computational designs into experimental reality through close collaboration with our in-house wet-lab and translational research teams.
Core Responsibilities:
- Pipeline Architecture: Develop and deploy robust computational pipelines for de novo protein and peptide design, utilizing state-of-the-art generative models.
- Lead Optimization: Leverage sequence- and structure-based modeling to predict stability, folding, and binding properties for therapeutic leads.
- Design-Build-Test: Drive iterative cycles by interpreting experimental data from production teams to refine and improve AI model performance.
- Technical Leadership: Shape the technical roadmap for the group's AI capabilities and mentor junior computational scientists.
Required Qualifications:
- Ph.D. in Computational Protein Design, Structural Biology, Bioinformatics, or a related field.
- 5 years of hands-on experience in macromolecular modeling and sequence/structure prediction.
-Technical Proficiency: Expert-level experience with modern tools such as AlphaFold, RoseTTAFold, RFdiffusion, or ProteinMPNN.
- Collaborative Track Record: Proven ability to work alongside experimental biologists and translate "in silico" results into actionable "in vitro" benchmarks.
- Therapeutic Insight: A strong understanding of protein folding, stability, and the constraints of drug development. Equal Opportunity Employer / Disabled / Protected Veterans
The Know Your Rights poster is available here:
_EEOC_KnowYourRights6.12.pdf
The pay transparency policy is available here:
_ English_formattedESQA508c.pdf
For temporary assignments lasting 13 weeks or longer, AllSTEM Connections is pleased to offer major medical, dental, vision, 401k and any statutory sick pay where required.
We are committed to working with and providing reasonable accommodations to individuals with disabilities. If you need a reasonable accommodation for any part of the employment process, please contact your staffing representative who will reach out to our HR team.
AllSTEM Connections participates in the E-Verify program in certain locations as required by law. Learn more about the E-Verify program.
_Participation_Poster_ES.pdf
We also consider for employment qualified applicants regardless of criminal histories, consistent with legal requirements, including, if applicable, the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance. Pursuant to applicable state and municipal Fair Chance Laws and Ordinances, we will consider for employment-qualified applicants with arrest and conviction records, including, if applicable, the San Francisco Fair Chance Ordinance. For Los Angeles, CA applicants: Qualified applications with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act.
Additional Skills
(none specified)
AllSTEM Representative Contact Info
Account Executive:
Giampaolo
Branch Phone:
Location:
Ontario, CA