Research Technologist

Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. The Translational Research Technologist in this position will carry out research on two major clinical problems: 1) the further development of a first effective therapy for a devastating thrombotic microangiopathy known as the childhood hemolytic uremic syndrome (eHUS), and 2) the study of von Willebrand Disease, the most common inherited bleeding disorder. Work for 2) encompasses laboratory microfluidics and biochemistry combined with clinical bleeding assessments and the obtaining of informed consent for research trials. We are presently examining the little understood role of the von Willebrand factor (VWF) pro-peptide in bleeding and clotting, and the function of VWF as an anti-angiogenic factor that, when deficient, may lead to unregulated angiogenesis and increased bleeding from fragile blood vessels in mucous membranes. Work for 1) involves the pursuit of novel therapeutic targets for eHUS by means of a genetically modified mouse model and an all-human endothelial cell culture model. The laboratory utilizes cell cultures of human endothelial cells, ELISAs for clotting factor activities, controlled hemodynamics of blood flow, fluorescence digital video-microscopy, real-time digital image processing (e.g., antigen co-localization) using a state-of-the-art imaging system, an ex vivo flow chamber to simulate flow in arteries, human arterioles, and MetaMorph Premier digital imaging software. This is a great opportunity for either a pre-medical student interested in translational research, or for a young investigator who seeks a medical research career. The lab director is a senior pediatric hematologist and an experienced scientist. Also overseeing the translational work is a senior medical hematologist. An applicant for this position should have a background in biology, chemistry, or related other medical science. Job Summary Summary Carries out a broad range of technically advanced research activities and procedures; evaluates conclusions and has considerable latitude to modify or devise methods and techniques as necessary to achieve desired results; typically supervises technical and sometimes administrative elements of the research unit. Helps onboard new staff and train them in the lab. Does this position require Patient Care? No Essential Functions -Develop or have input into modifications of existing assay techniques, experimental protocols, or new procedures. -Synthesizes and interprets results. -Prepares written and/or verbal status reports. -Performs statistical analysis and makes recommendations. -Independently performs non-routine, highly specialized experimental procedures. -Composes and may present sections of research reports and manuscripts. -Performs other duties as assigned. -Complies with all policies and standards. Qualifications Education Bachelor's Degree related Field of Study required Can this role accept experience in lieu of a degree? Yes Licenses and Certifications Experience Experience in an academic or laboratory research setting 3-5 years required Knowledge, Skills and Abilities -Excellent communication skills. -Good interpersonal skills and the ability to oversee the work of others. -Ability to work independently. -Ability to identify problems and develop solutions. -Ability to prioritize tasks and set deadlines. -Strong database management and overall computer skills. -Functions with speed, precision and an understanding of theory behind tests and procedures. Additional Job Details (if applicable) Principal Duties and Responsibilities: Maintain endothelial cell cultures. Study tissue sections from a unique, genetically modified mouse model. Complete assignments from the laboratory director and other lab personnel in research projects. Perform ELISAs for complement and tissue factor activity. Perform digital image analysis of platelet-endothelial cell interactions in flowing blood as well as with fixed sections of organ tissue. Collect and accurately record procedures and results, Maintain databases used in the lab, Order and manage the use of necessary reagents. Participate in and present data at weekly lab meetings and journal clubs. Analyze results and begin interpretation of these results. Participate in general oversight of the lab. Perform other duties as assigned. Skills/Abilities/Competencies Required: Experience with sterile cell culture techniques and with current approaches used in basic molecular biology and biochemistry is helpful. Knowledge of convective diffusion and principles of digital image analysis is helpful. Ability to build upon present knowledge bases. Desire to learn new, state-of-the-art imaging techniques. Desire to learn basic and novel research approaches. Able to work as part of a team, but also independently when necessary. Ability to follow instructions, work accurately, and meet deadlines. Proficiency in Excel, Word, PowerPoint, and statistical software is desirable. Remote Type Onsite Work Location 32 Fruit Street Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) EEO Statement: The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.