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4DMT is a clinical–stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid–derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.
We have built a deep portfolio of AVV–based gene therapy product candidates, with five product candidates in clinical trials: 4D–150 for the treatment of wet age–related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D–710 for the treatment of cystic fibrosis lung disease, 4D–310 for the treatment of Fabry disease cardiomyopathy, 4D–125 for the treatment of X–linked retinitis pigmentosa (XLRP), and 4D–110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D–175 for geographic atrophy (GA) and 4D–725 for alpha–1 antitrypsin deficiency.
To–date, we have demonstrated clinical proof–of–concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.
In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.
Company Differentiators:
• Fully integrated clinical–phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre–clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY:
The Director, Clinical Science will be integral in facilitating the successful advancement of clinical gene therapy programs. The position supports clinical and scientific aspects of all assigned clinical programs.
RESPONSIBILITIES:
QUALIFICATIONS:
Education:
Experience:
Skills:
Base salary compensation range:
Outside of SF Bay Area range: $200,000/yr – $240,000/yr
Bay Area Range: $220,000/yr – $270,000/yr
Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate's geographical location, relevant work experience, skills, and years of experience.
4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with DisabilitiesFull Time
Scientific Services
$166k-215k (estimate)
05/18/2024
06/06/2024
4dmoleculartherapeutics.com
EMERYVILLE, CA
50 - 100
2013
Public
DAVID KIRN
$10M - $50M
Scientific Services
4DMT is a biotechnology company that researches, develops and commercializes gene therapeutics for the treatment of cancer.
The job skills required for Director, Clinical Science include Leadership, Collaboration, Clinical Trial, Clinical Operations, etc. Having related job skills and expertise will give you an advantage when applying to be a Director, Clinical Science. That makes you unique and can impact how much salary you can get paid. Below are job openings related to skills required by Director, Clinical Science. Select any job title you are interested in and start to search job requirements.
The following is the career advancement route for Director, Clinical Science positions, which can be used as a reference in future career path planning. As a Director, Clinical Science, it can be promoted into senior positions as a Top Clinical Research Executive that are expected to handle more key tasks, people in this role will get a higher salary paid than an ordinary Director, Clinical Science. You can explore the career advancement for a Director, Clinical Science below and select your interested title to get hiring information.