What are the responsibilities and job description for the Principal Scientist, Chemistry (Medicinal Chemistry) position at Z-Alpha Therapeutics?
Z-Alpha Therapeutics is a pharmaceutical company dedicated to the discovery and development of radiotherapeutics targeting key biological pathways for solid tumors. The company has a revolutionary technology platform in the next generation of alpha particle therapy with potential to be a more targeted therapy, increasing efficacy and limiting toxicity compared to competitors in the radiotherapeutics space. The company has a world-class team of scientists with decades of experience and foundational intellectual property that enables the potential to bring multiple drug candidates into the clinic.
Position Overview :
We are looking for a highly experienced and innovative Principal Scientist in Chemistry to lead our drug discovery efforts. The ideal candidate will possess extensive expertise in medicinal chemistry and a proven ability to drive projects from early discovery through preclinical development. This position requires strong leadership, strategic insight, and effective collaboration across multidisciplinary teams.
Key Responsibilities :
- Lead and oversee the design, synthesis, and optimization of small molecule drug candidates.
- Develop and implement medicinal chemistry strategies to enhance the drug discovery pipeline.
- Collaborate closely with cross-functional teams, including biology, pharmacology, and toxicology, to advance projects.
- Utilize structure-activity relationship (SAR) studies to inform and guide compound optimization.
- Engage in laboratory work, with up to 50% of your time dedicated to hands-on research.
- Analyze complex datasets, interpret experimental outcomes, and present findings at project team and company-wide meetings.
- Maintain rigorous records of experiments, ensuring data integrity, reproducibility, and adherence to regulatory standards.
- Provide scientific guidance and mentorship to junior team members, fostering a collaborative and innovative research environment.
- Establish and manage laboratory infrastructure and standard operation process.
- Stay abreast of industry trends and advancements in medicinal chemistry to inform project strategies.
Qualifications :
Join us at Z-Alpha Therapeutics and contribute to innovative solutions that redefine the landscape of cancer treatment!