What are the responsibilities and job description for the Scientist, Antibody Discovery and Engineering position at Work In Biotech?
Scientist-Antibody Discovery and Engineering
Location: San Francisco, CA (on-site position)
Company: Stealth-mode biotechnology venture
Role Overview
A stealth-mode biotechnology company in San Francisco is seeking a highly motivated Scientist to join their Antibody Discovery and Engineering team. The successful candidate will contribute to the discovery and optimization of therapeutic antibodies using advanced technologies such as phage/yeast display, mutagenesis, and integrated leads screening. This role offers an exciting opportunity to work in a fast-paced environment focused on developing next-generation biologics. This is an on-site position.
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Key Responsibilities:
- Lead VHH and related discovery campaigns using yeast and phage display technologies, including experimental design, execution, and troubleshooting.
- Perform hands-on antibody discovery workflows, including library construction, panning, output screening, single-clone characterization, and data summarization.
- Analyze binding kinetics, specificity, and stability of antibody leads using biochemical and biophysical assays such as SPR, BLI, ELISA, and cell-binding studies.
- Accurately document experiments and maintain electronic lab notebooks (Benchling) in a timely manner.
- Conduct in-depth data analysis and effectively communicate results in project meetings, ensuring alignment with timelines and goals.
- Collaborate with cross-functional teams (protein science, biology, and in vivo pharmacology) to optimize antibody properties.
- Coordinate with CROs on activities related to animal immunization, protein production, and characterization.
- Performs additional duties as assigned.
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Basic Qualifications:
- Education: Master’s degree in Biology or a related field with 5 years of experience in antibody discovery, or a Ph.D. with 2 years of relevant experience.
- Proven ability to design and apply in vitro antibody discovery display technologies (e.g., phage display, yeast display) for antibody discovery and/or engineering.
- Strong molecular biology skills, including PCR, DNA/RNA isolation, plasmid preparation, gel extraction, cloning, and Sanger sequencing analysis.
- Hands-on experience with SPR (Carterra LSA, Biacore) or BLI (Octet, Gator), ELISA and flow cytometry.
- Demonstrated scientific productivity and independence, with strong problem-solving skills.
- A strong desire to work in a dynamic startup environment is essential.
- Comfortable working in an environment involving radiolabeled therapeutics.
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Preferred Qualifications:
- Strong communication skills to work within a multidisciplinary team environment.
- Experiences leading project from antibody discovery to drug candidate selection.
- Knowledgeable in recombinant protein production and characterization
- Proficiency with bio-tools such as GraphPad Prism, Geneious, FlowJo and Benchling.
- Demonstrated track record in managing multiple projects and prioritizing tasks to meet schedules and timelines.
- Excellent written and oral communication skills and the ability to present effectively to teams.
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Leveling & Compensation
- Title and scope commensurate with experience
- Competitive compensation package including equity participation
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Why Join Us
- Opportunity to shape the antibody discovery engine of a cutting-edge radioligand therapy company.