What are the responsibilities and job description for the Postdoctoral Researcher position at West Virginia University?
Postdoctoral fellowship in synaptic biology and super-resolution imaging in models of Alzheimer’s disease
The Hruska Laboratory in the Department of Neuroscience at the West Virginia University School of Medicine is recruiting a postdoctoral researcher to join an exciting, fully funded program supported by the National Institute on Aging(NIA). This position offers an outstanding opportunity to lead a high-impact project investigating the molecular architecture of synapses using advanced approaches, including STED super-resolution microscopy.
Our work seeks to uncover core mechanisms that govern synapse function and plasticity, with a particular focus on nanoscale organization of dendritic spines. We aim to understand how these highly organized molecular structures become disrupted in Alzheimer’s disease (AD), and how these structural changes translate into synaptic dysfunction, reduced plasticity, circuit instability, and ultimately cognitive decline and memory impairment. Our recent findings reveal striking synapse-specific vulnerability to amyloid-beta (Aβ), suggesting the existence of an underlying molecular logic that remains to be defined. To uncover these mechanisms, we integrate molecular biology, biochemistry, CRISPR-based genome engineering, and advanced imaging in living and fixed neurons, directly linking nanoscale synaptic organization to functional outcomes.
We are seeking a highly motivated, intellectually curious, and creative scientist who is eager to lead an ambitious project. The successful candidate will hold a Ph.D. in neuroscience or molecular and cellular neurobiology, have at least one first-author publication in a peer-reviewed international journal, and possess strong expertise in molecular and cellular neuroscience. Candidates who are about to complete their Ph.D. are encouraged to apply. The ideal applicant is independent, rigorous, and excited to build a research program that connects molecular, cellular, and circuit-level neuroscience.
Department of neuroscience offers a highly collaborative, intellectually vibrant, and deeply supportive scientific environment, with access to state-of-the-art infrastructure. Hruska laboratory is committed to mentorship, career development, and fostering scientific independence. This position is fully funded, ensuring long-term stability and continuity for the project. At the same time, we actively encourage and support the successful candidate in applying for competitive fellowships, as part of their professional growth and transition toward research independence.
For details about the position or to apply, please email your CV and a cover letter detailing your experience and interest in the position directly to Dr. Martin Hruska.
Qualifications
Required
- Ph.D. in neuroscience, molecular biology, biochemistry, or a related field
- Experience working with molecular cloning/engineering of DNA constructs
- Confocal microscopy (understanding of super-resolution modalities strongly preferred)
- Ability to work independently – including designing experiments, analyze data, and write manuscripts