Scientist II

Wave Life Sciences USA, Inc. seeks Scientist II for Cambridge, MA location. Duties include: Lead therapeutics projects for platform development and oligonucleotide drug development to treat severe genetic diseases; Organize and drive communication and coordination within a cross-functional team to solve a complex issue and advances projects towards the milestones; Oversee, guide, and support the discovery, research, and development of siRNA therapeutics targeting peripheral extra-hepatic tissues; Independently conceptualize, initiate and execute preclinical research and discovery plan, and drive therapeutics program through pre-defined milestones until lead nomination. Position requires a Master’s Degree, or foreign equivalent, in Pharmaceutical Sciences, Bioengineering, Biomedical Sciences, Biology, or related field and 7 years of experience in nucleic acid therapeutic research and development.

Experience must include the following (may be gained concurrently):

• 7 years’ experience in discovery and research of oligonucleotide therapeutics in in-vitro models for CNS diseases to include 3 years ‘experience in research and development of siRNA therapeutics targeting liver, CNS, and peripheral extra-hepatic tissues;
• 7 years’ experience conducting platform development and mechanistic studies to improve efficacy and potency of oligonucleotide therapeutics including ASOs (antisense oligonucleotides), to include 3 years’ experience with siRNAs and in vitro and in vivo optimization of extra-hepatic delivery of siRNA;
•  7 years’ experience drafting and revising Standard Operating Protocols (SOPs) for biological studies to include 3 years’ experience drafting and revising SOPS with in-vivo sample processing for transcript and protein study; 
• 7 years’ experience in qualitative and quantitative analysis of ASO mediated studies involving high throughput screening (in-vitro);
• 7 years’ experience in evaluating supplies and equipment to ensure operability in a laboratory setting, to include High Throughput liquid handlers such as RNA extraction kits, manipulation kits and reagents (enzymes and buffers);
• 5 years’ experience in generation and optimization of  iPSC derived neurons, to include 2 years’ experience in cell culture and maintenance of hepatocyte, and different extra-hepatic primary cells;
• 2 years’ experience processing samples from in vivo oligonucleotide studies including assays for PK/PD, toxicity, and target engagement ;   
• 2 years’ experience in research and development of siRNA therapeutics for common and rare metabolic diseases including chronic liver disease, metabolic disorders, and inborn error to including 2 years’ experience in development and optimization of assays evaluating metabolic parameters in both in vitro and in vivo samples;
• 2 years’ experience organizing and driving communication and coordination of multi-functional units as point of contact for oligonucleotide  drug discovery projects;
• 1 year experience is required in working with guide and mentor  junior scientists for scientific and technical training, workload assignment and management, monitoring of study execution, data analysis and communication; 
• A record of publication in siRNA platform development, including publication of at least 1 manuscript in a high-profile scientific journal and filing of at least 5 patents (provisional and/or published).

Pay Range External Disclosure Statement

The annual base salary range for this position is $117,465.50-120,802.

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Salary : $117,466 - $120,802