Demo

Payroll Manager

Vaco by Highspring
San Diego, CA Full Time
POSTED ON 5/28/2026
AVAILABLE BEFORE 7/2/2026

Title: Payroll Manager

Company Industry: Life Sciences

Compensation: 105-115k base salary DOE

Location: La Jolla, CA


Position Overview

Our client, a growing organization within the life sciences and research space, is seeking a Payroll Supervisor to lead payroll operations and oversee a small payroll team. This individual will play a key role in supporting a rapidly scaling employee population and ensuring accurate, compliant, and timely payroll processing across a complex, multi-state environment.

The ideal candidate is hands-on, adaptable, and experienced managing high-volume payroll operations with strong attention to detail and a collaborative mindset.


Key Responsibilities

  • Lead, mentor, and oversee payroll staff, including workload management, coaching, and performance oversight
  • Manage end-to-end payroll processing for salaried, hourly, and stipend-based employees
  • Ensure compliance with federal, state, and local payroll regulations across a multi-state workforce
  • Review payroll data including timekeeping, compensation updates, deductions, and employee changes
  • Maintain payroll records and ensure integrity within payroll systems
  • Partner closely with HR, Finance, Benefits, and other cross-functional teams to resolve payroll matters and support employee inquiries
  • Conduct payroll audits and reconciliations to ensure accuracy and compliance
  • Prepare payroll reporting and support leadership requests as needed
  • Oversee payroll and tax compliance related to foreign national employees and non-employees
  • Administer Glacier, including treaty application tracking, tax residency determinations, and required documentation
  • Support year-end and periodic tax reporting, including 1042 and 1042-S filings
  • Assist with payroll process improvements, policy development, and operational best practices


Must-Have Qualifications

  • Experience processing high-volume payroll in a complex environment, ideally supporting significant organizational growth
  • Strong knowledge of multi-state payroll compliance, including experience supporting employees across numerous states
  • Ability to adapt quickly in a fast-paced, evolving environment with shifting priorities
  • Proven ability to maintain accuracy and meet strict payroll deadlines under pressure
  • Minimum 3 years of recent payroll supervisory experience, including team leadership and performance management
  • Experience partnering cross-functionally with HR, Finance, Benefits, and related teams


Preferred Qualifications

  • Bachelor's degree in Accounting, Finance, Business Administration, or related field preferred
  • 5 years of progressive payroll experience
  • Experience with payroll systems such as Workday and/or UKG
  • Advanced Excel and systems proficiency
  • CPP certification preferred
  • Experience supporting international or foreign national payroll processes is a plus

Salary.com Estimation for Payroll Manager in San Diego, CA
$122,144 to $157,473
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