Demo

Scientist II

US Tech Solutions
South San Francisco, CA Contractor
POSTED ON 4/5/2025
AVAILABLE BEFORE 5/4/2025
Key Responsibilities:
  • Design and perform plate-based and cell-based assays (multi-color flow cytometry, Western blot, ELISA, etc.) to assess mRNA delivery and protein expression in mammalian cells using LNP systems.
  • Design and perform high-throughput expression and functional screen/characterization assays for protein/mRNA candidates, using semi-automated instruments.
  • Maintain meticulous records in an electronic lab notebook (ELN), draft standard operating procedures (SOPs), and present results at team meetings.
  • Independently plan, execute, and interpret experiments, delivering data-driven insights aligned with project timelines and goals.
  • Conduct molecular biology tasks, including cloning (e.g., PCR, golden gate, Gibson reactions, etc.), and optimize mRNA IVT protocols for yield and quality.
  • Design, produce, and optimize lentiviral vectors, perform transduction experiments, and analyze results to advance research objectives.
  • Stay current with advancements in genetic medicine, LNP technology, and molecular biology techniques to inform experimental design.
  • Collaborate with antibody discovery/production teams to support pipeline projects and facilitate technology hand-offs.
Qualifications:
  • Master’s degree in Cell Biology, Molecular Biology, Biological Sciences, or a related field with 1-3 years of industry experience, OR Bachelor’s degree in a related field with 3 years of industry experience.
  • Expertise in mammalian cell culture (suspension and adherent cell lines, primary T cells) and multi-color flow cytometry (panel design, acquisition, and analysis using FlowJo) is required; Hands-on experience with immunological assays (e.g., ELISA, Luminex, cytotoxicity) is highly desirable.
  • Experience with semi-automated liquid handling systems (e.g., Integra VIAFLO) for high-throughput workflows is highly preferred.
  • Familiarity with data analysis tools (e.g., GraphPad Prism, FlowJo) is required; working knowledge with statistical and bioinformatics tools (python, R, etc.) is a plus.
  • Basic understanding of immunology, cancer biology, or cell therapy applications is preferred; Prior experience in genetic medicine, CAR-T cell therapy, or RNA therapeutics is a strong plus.
  • Basic knowledge of nucleic acid characterization (e.g., gel electrophoresis, qPCR), familiarity with molecular biology techniques, including cloning (e.g., Gibson assembly, PCR) and mRNA IVT (e.g., capping, purification), is a strong plus.
  • Strong organizational and time-management skills with a proven ability to juggle multiple projects.
  • Demonstrated ability to troubleshoot assays and optimize protocols independently.
  • Excellent verbal and written communication skills for presenting data and collaborating with cross-functional teams.
  • Willingness to take responsibilities outside of original job description.
About US Tech Solutions:
US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com.

US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

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