VP, Asset Lead UTUC

Tyra Biosciences, Inc. is seeking a highly motivated VP, Asset Lead to make impactful contributions to oncology drug development projects targeting disease areas with high unmet medical need. The successful candidate will be highly organized, self-motivated, and thrive in a dynamic, cross-functional start-up environment.

This position requires broad knowledge and experience across the clinical development spectrum, specifically late-stage development. This individual is the matrix leader with overall, end-to-end accountability for a drug's development, from late-stage clinical trials through registration, launch, and life cycle management. At the P3 stage, the VP, Asset Lead will focus on generating integrated evidence for regulatory submission, optimizing commercial strategy, and ensuring cross-functional alignment to maximize the asset's value.

Job Responsibilities

• Strategic Leadership: Develops and executes the comprehensive Global Asset Strategy (GAS) and Phase 3 clinical development strategy, ensuring alignment with commercial and regulatory goals.
• Matrix Team Management: Chairs the Asset Strategy Team (AST), guiding cross-functional teams (Clinical, Regulatory, Commercial, CMC, Supply Chain) to deliver on milestones.
• Governance and Decision Making: Acts as the primary point of contact for senior management and governance bodies, providing data-driven recommendations (Go/No-Go decisions) and mitigating high-impact risks.
• Budget and Resource Management: Oversees the asset budget, ensuring the program is adequately resourced and aligned with Portfolio Committee priorities.
• Regulatory/External Engagement: Represents the program at key regulatory meetings, Advisory Boards, and in interactions with corporate partners.
• Commercialization Prep: Partners with Commercial teams to ensure market readiness, including developing the product value proposition, label strategy, and lifecycle management plan.

Minimum Requirements

• Advanced Degree in scientific/life-sciences field with a Master’s, PharmD, Ph.D., MD or MBA degree highly preferred.
• Large, global, late-stage Oncology Drug Development (P3) experience required. Experience with urothelial cancers a plus
• 12 years of experience in the pharmaceutical/biotech industry, with a focus on drug development, clinical operations, or commercialization.
• 8 years experience leading cross-functional or matrixed teams, with a track record of driving decision-making without direct reporting authority.
• Strong understanding of P3 clinical trial design, global regulatory requirements (e.g., FDA/EMA), and commercialization strategies.
• Prior experience working in a small, start-up biotech work environment preferred.
• Ability to synthesize complex data into a cohesive, long-term plan.
• Expert in building consensus across diverse stakeholders.
• Proactively identifies risks and develops mitigation strategies.
• Excellent written and oral communication skills
• Strong analytical and strategic ability
• Ability to work independently and to multi-task large projects or compounds, ability to change pace and tasks as needed, and to work in a fast-paced environment
• Have proven ability to collaborate and communicate effectively in a fast-paced environment.
• Ability to accommodate up to 20% travel or as business dictates

Pay Range and Benefits

Base Salary Range: $346,500 - $362,700 USD

Individual compensation will be determined based on factors such as work location, skills, education, training, and experience.

What we offer US-based Employees:

• Competitive base, bonus, new hire and ongoing equity packages
• The starting compensation range(s) for this role is for a full-time employee (FTE) basis
• Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment
• Employer-paid Medical, dental, and vision insurance
• Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage
• 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions
• Employee Stock Purchase Plan
• 14 -18 paid holidays, including office closure between December 25th and January 1st
• Flexible vacation
• Sick time
• Fitness Program
• Get Outdoors Program
• Paid parental leave benefit
• Tuition assistance

Job Type: Full-Time

Work authorization: United States (Required)

Work Location: Remote

Equal Opportunity Employer: Tyra Biosciences, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies: The Talent Acquisition team manages the recruitment and employment process for Tyra. To protect the interests of all parties involved, Tyra will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Tyra employees directly in an attempt to present candidates. Tyra will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.