What are the responsibilities and job description for the Manager, Antibody Characterization position at Twist Bioscience?
Manager, Antibody Characterization (onsite in Quincy, MA)
Job Description
This is a management position that provides support for bioanalytical characterization for a variety of therapeutic antibody candidates. This role oversees our Antibody Characterization team and is responsible for managing, optimizing, and troubleshooting a range of workflows, including immunoassays, affinity analysis, functional assays, and target binding characterization.
Essential Functions
Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.
Job Description
This is a management position that provides support for bioanalytical characterization for a variety of therapeutic antibody candidates. This role oversees our Antibody Characterization team and is responsible for managing, optimizing, and troubleshooting a range of workflows, including immunoassays, affinity analysis, functional assays, and target binding characterization.
Essential Functions
- Lead, manage, and develop a team of scientists and research associates in our Antibody Characterization department.
- Provide technical guidance (assay development, analysis, and data reporting) in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), advanced/custom characterization, and functional screening.
- Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
- Review, critically analyze, and present data to customers to facilitate antibody lead selection for a variety of concurrent antibody discovery programs.
- Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
- Work closely with all scientific departments and senior management to ensure excellent management of all activities and effective communication.
- Promote operational and scientific excellence by driving continuous process improvement.
- Stay up to date with recent developments in antibody discovery methods and technologies, and help guide the advancement of our laboratory capabilities in alignment with strategic company goals.
- Spend approximately 30-50% of your time performing wet-lab benchwork alongside the team.
- PhD in a related technical field with 3 years of management experience in biopharmaceutical analytical development, or MS with 5 years of experience, including 3 years of management experience.
- Expert knowledge of biologics characterization assays: extensive hands-on experience required in ELISA, flow cytometry, and SPR/BLI with Carterra and Sartorius Octet.
- Very strong track record of developing, executing, and analyzing common assay formats for biologics discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
- Able to independently manage and prioritize tasks in a fast-paced environment that hinges on overlapping projects and sensitive workflow timelines.
- Advanced understanding of in vivo antibody discovery concepts.
- Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
- Proven management skills for both projects and people, with a strong track record of building trust and developing teams at a variety of levels.
- Exceptional written and verbal communication skills, including customer-facing communication.
- Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.
Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.