Demo

Equipment Engineer

Twist Bioscience
South San Francisco, CA Full Time
POSTED ON 6/12/2026
AVAILABLE BEFORE 7/10/2026
Equipment Engineer (onsite in South San Francisco, CA )

Job Description

The Equipment Engineer is responsible for ensuring the reliability and performance of all production instrumentation within a high-throughput DNA synthesis environment. You will be the primary lead for validating equipment, performing routine and preventative maintenance, and executing complex troubleshooting to minimize downtime.The ideal candidate is a self-motivated problem-solver who thrives in a fast-paced setting and is committed to maintaining the rigorous quality metrics required for cutting-edge biotechnology production.

What You’ll Be Doing

  • Equipment Validation: Lead the execution of Installation Qualification (IQ), Operational Qualification (OQ), and Performance Qualification (PQ) for both new and existing instrumentation.
  • Preventative Maintenance: Manage the scheduling and execution of routine maintenance and calibrations in strict accordance with manufacturer specifications and internal quality standards.
  • Troubleshooting: Investigate recurring equipment failures to implement permanent engineering fixes, significantly reducing or eliminating downtime.
  • Quality Compliance: Own and ensure the timely closure of equipment-related CAPAs (Corrective and Preventive Actions) and Change Controls.
  • Inventory & Logistics: Instrument, spare part, and service purchasing, from order submission to receipt of goods.
  • Cross-Functional Collaboration: Partner closely with Process Engineers to understand equipment-process interactions and ensure hardware operates within peak specifications.

What You’ll Bring To The Team

  • Education: BS in Engineering, Physical Sciences, or a related technical discipline.
  • Experience: Minimum of 1-3 years of professional experience in equipment maintenance, calibration, and repair.
  • Technical Versatility: Proven ability to design and build projects to improve reliability using mechanical, electrical, and electro-mechanical systems
  • Quality Mindset: High attention to detail and strong organizational skills; experience working under ISO 9001, ISO 13485, or GMP/cGMP standards is highly preferred.
  • Adaptability: Ability to multi-task in a dynamic environment and work comfortably in a cleanroom setting (requiring lab coats, hairnets, and gloves).
  • Good computer skills (Excel, Word, Atlassian etc) and the ability to quickly learn new software applications.
  • Communication: Excellent interpersonal skills with a collaborative approach to problem-solving.
  • Strong documentation experience, drafting technical documentation, and managing maintenance records.
  • Bonus Assets: Experience with automated liquid handlers, robotics, or MES/LIMS integration is a significant plus.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.

San Francisco Bay Area Pay Range

$104,600 - $128,400 USD

Salary : $104,600 - $128,400

If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

What is the career path for a Equipment Engineer?

Sign up to receive alerts about other jobs on the Equipment Engineer career path by checking the boxes next to the positions that interest you.
Income Estimation: 
$92,472 - $113,500
Income Estimation: 
$110,728 - $138,540
Income Estimation: 
$92,472 - $113,500
Income Estimation: 
$110,728 - $138,540

Sign up to receive alerts about other jobs with skills like those required for the Equipment Engineer.

Click the checkbox next to the jobs that you are interested in.

  • Applied Mechanics Skill

    • Income Estimation: $135,163 - $163,519
    • Income Estimation: $166,631 - $195,636
  • Computer Simulation Skill

    • Income Estimation: $97,688 - $130,047
    • Income Estimation: $83,633 - $115,564
Employees: Get a Salary Increase
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at Twist Bioscience

  • Twist Bioscience Portland, OR
  • Reporting to the Global Collections Manager, the Collections Analyst will be responsible for timely collections across a portfolio of accounts, including f... more
  • 4 Days Ago

  • Twist Bioscience South San Francisco, CA
  • We are seeking a highly analytical, proactive, and strategic Senior Production Planner to own and optimize the end-to-end workflow of our standard Librarie... more
  • 6 Days Ago

  • Twist Bioscience South San Francisco, CA
  • Sr. Director, Customer Relationship Management Job Description We are seeking an experienced and highly motivated executive to lead the strategic developme... more
  • 7 Days Ago

  • Twist Bioscience South San Francisco, CA
  • The Staff Product Manager will be responsible for all aspects of product management for Twist Bioscience Protein Solutions product portfolio. This includes... more
  • 8 Days Ago


Not the job you're looking for? Here are some other Equipment Engineer jobs in the South San Francisco, CA area that may be a better fit.

  • Peak Energy San Francisco, CA
  • Job Title: Manufacturing Equipment Engineer Location: Burlingame, CA Department: Manufacturing Engineering Reports to: Manufacturing Equipment Engineering ... more
  • 7 Days Ago

  • Intuitive San Francisco, CA
  • Company Description It started with a simple idea: what if surgery could be less invasive and recovery less painful? Nearly 30 years later, that question s... more
  • 8 Days Ago

AI Assistant is available now!

Feel free to start your new journey!