What are the responsibilities and job description for the Postdoctoral research fellow (Lab) position at Tufts Medical Center?
The Molecular Cardiology Research Institute (MCRI) at Tufts Medical Center in Boston, invites post-doctoral applications for a position to study cerebral vascular function during acute and chronic diseases in the laboratory of Dr. Miranda Good. The overall objective of the Good Lab is to understand the mechanisms that regulate blood vessel function and inflammation during disease states, such as ischemic stroke and Alzheimer’s disease. The vasculature regulates post-ischemic injuries through recovery of blood flow and inflammation. Pannexin1 (Panx1) channels are nucleotide release channels that, until recently, have only generally been implicated in ischemic outcomes. However, our current work has demonstrated that deletion of endothelial Panx1 significantly reduces ischemia/reperfusion injury in brain, heart, lung, and kidney. The lab focuses on evaluating the role and regulation of Pannexin 1, a potential novel therapeutic target, within arterial and venous endothelial cells and how it contributes to the etiology of ischemic injuries and vascular-mediated progression of Alzheimer’s disease.
A highly motivated Postdoctoral Research Fellow is sought, ideally with prior experience in cardiovascular or neurovascular physiology. The laboratory uses state of the art molecular and cellular biology assays, ex vivo vascular function studies, and state-of-the-art mouse models of vascular injury and ischemic injuries to address clinically relevant questions in vascular biology and physiology. Prior experience in pressure myography on resistance arteries and/or survival surgeries in mice or rats is preferred but not required.
The successful applicant will work closely with the Principal Investigator on research projects studying the vascular mechanisms contributing to detrimental outcomes following an ischemia/reperfusion injury or during Alzheimer’s disease. As needed, the individual will be required to independently develop protocols and establish new methodologies in the laboratory. The applicant would be intimately involved in writing and presenting new discoveries. The lab has a pending R01 and R03 that will support the lab.
The position requires:
MD, PhD or both required
Excellent writing and communications skills
Prior experience in animal physiology
The MCRI is an internationally known institute with several principal investigators studying diverse topics of cardiology and vascular medicine. Dr. Good is also part of the Neuroscience program at Tufts University School of Medicine. The fellow will work closely with the principal investigator, her lab, and other members of the MCRI and Neuroscience departments. Please visit our websites at: https://www.tuftsmedicine.org/research-clinical-trials/research-institutes-research-department/mcri-homepage/mcri-investigators/good-laboratory and https://facultyprofiles.tufts.edu/miranda-good.