Scientist, Structural Biology

About Treeline

Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life-threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, lead discovery, medicinal chemistry, and computation to reduce the time and risks of drug discovery.

About the role

We are seeking an experienced, enthusiastic, and highly motivated Scientist to join our Watertown, MA structural biology group to support the team’s delivery of high-quality scientific data that drive small molecule drug discovery. The successful candidate will have a critical role in supporting Treeline’s drug discovery programs by collaborating closely with the multi-disciplinary Lead Discovery organization across biophysics, mass spec, biochemistry, structural biology, and protein production, as well as the broader organization including biology, computational chemistry, and medicinal chemistry. The ideal candidate will take a lead on lab equipment operation/maintenance, execute on structural experiments, and effectively communicate results to colleagues within Lead Discovery and project teams.

Responsibilities

• Establish protein crystallization conditions for small molecule soaks/co-crystallization and solve high resolution crystal structures to drive structure-based drug design.
• Maintain day-to-day operation of the structural biology laboratory and equipment.
• Provide insights and guidance to build the capabilities of the structural biology platform.
• In collaboration with project teams, establish SAR to rapidly drive the hit finding, hit-to-lead, and lead optimization process.

Qualifications

• PhD in Structural Biology, Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 0 years or BS/MS with 6 years experience in biotech/pharma industry.
• Training in crystallographic workflow: screening, crystal harvesting, ligand complexing, data collection and processing, and structure refinement.
• Experience with a Linux cloud computation environment – knowledge of databases and Python/shell scripting is a plus.
• Ability to maintain and operate sensitive lab equipment, like liquid handlers, automated imagers, and microscopes.
• Ability to work efficiently and communicate detailed results within defined timelines and to collaborate in a multidisciplinary team.
• Experience with fragment screening or novel crystallographic workflows is a plus.
• Additional experience with protein purification, biophysical methods (SPR, DSF, MST, ITC), or other structural characterization technique (cryoEM/NMR/SAXS) is a plus.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $126,087 to $139,666. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through Skype or Telegram.
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• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters)

The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.