Postdoctoral Associate | Beck Lab

The Beck Lab is seeking an enthusiastic, independent, and highly motivated postdoctoral fellow to join our innovative research group at the Jackson Laboratory for Genomic Medicine and University of Connecticut Health Center in Farmington, CT. The Beck lab uses and develops genomic and transcriptomic techniques to identify variation within repetitive and complex regions of mammalian genomes. As a postdoctoral fellow in the Beck lab, you would lead projects examining the mechanisms and consequences of structural variants across human and mammalian organisms. To accomplish these goals, the fellow will analyze existing genomic and transcriptomic data with computational tools to identify novel loci of interest, and will execute laboratory experiments to test the consequences of genomic variation. Fluency with multiple experimental techniques coupled with ability or a willingness to learn Python or R and common bioinformatics tools is required to carry out analyses and prepare results for publication. Experience with cell culture, and in particular iPSCs, will be beneficial for these projects. Key Responsibilities: Conduct cell culture, molecular biology and biochemistry experiments Maintain lab equipment, reagents, and follow safety protocols Author manuscripts and grant applications Present results at lectures and conferences Use bioinformatics tools to analyze genomic and transcriptomic data from human and mouse samples Interpret variation, variant mechanisms, and the effect of variants on transcription Contribute to project planning and implementation Perform data curation and maintain documentation Generate reproducible analysis and properly use statistics to support observations Collaborate with a multidisciplinary team of researchers who perform bench and computational experiments Preferred/bonus skills: Experience with iPSC culture and differentiation Knowledge of structural variation and variant mechanisms Experience using computational libraries for tabular data and statistical analysis Experience executing jobs and pipelines in a high-performance computing cluster Experience working in a Linux command-line environment Qualifications: PhD in Physiology, Molecular Biology, Genetics, Biomedical Engineering, or a related field Strong publication record in peer-reviewed journals Excellent communication and teamwork skills, with the ability to work independently and collaboratively Experience using statistical inference to support results Application Instructions: Please submit your current CV, at least 2 letters of reference, and a 1-page (maximum) statement JAX Salary: Year 0 - 1: $65,589 Year 1 - 2: $67,318 Year 2 - 3: $69,095 Year 3 - 4: $70,521 Year 4 - 5: $72,877 Year 5 - 6: $75,569 Based on years of experience as Postdoc About JAX: The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health. Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org. EEO Statement: The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws. Bar Harbor: The Jackson Laboratory's 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries. Ellsworth: The Charles E. Hewett Center in Ellsworth, Maine, is a state-of-the-art facility that serves researchers world wide. The facility represents the culmination of nine decades of unmatched experience and leadership in breeding and caring for laboratory mice. Ellsworth, Maine, is one of Maine’s fastest growing cities. With a growth rate of nearly 20%, Ellsworth is a bustling year-round community and acts as a hub for surrounding towns. It is located nearby Acadia National Park and hosts numerous special events, concerts and festivals each year. Residents have access to fabulous shopping, recreation, museums, galleries, and dining at a variety of independent restaurants. Farmington: JAX Genomic Medicine is transforming medicine by improving patient care, lowering costs, and increasing life span and health span. JAX Genomic Medicine’s research focuses on the complex genetic causes of disease and on the development of genomic solutions tailored to each person's unique genetic makeup. JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. The 183,500-square-foot facility opened in the fall of 2014. Now, it houses over 300 biomedical researchers, technicians, and support staff in state-of-the-art computing facilities and laboratories. In Connecticut, JAX resides in the scenic town of Farmington, in the state’s capitol region. The Hartford region, which offers some of the best public schools in the country, is made up of both bigger cities and smaller, charming historic New England towns. JAX Genomic Medicine is also geographically located within 2 hours of Boston and New York and is close to multiple transportation systems, including bus lines, highways, railroads and international airports. Sacramento: The JAX® Mice, Clinical and Research Services facility is located in Sacramento, the state capital of California. Sacramento is less than a two-hour drive from San Francisco, Napa Valley, and scenic Lake Tahoe, and a short flight to both Los Angeles and Orange County. Sacramento is the birthplace of the nation’s Farm to Fork movement, and offers excellent restaurants, gastro-pubs, wineries, theaters, and museums. Outdoor activities are plentiful: Boating, white water rafting, and riding the scenic bicycle trails are popular. Housing and other costs of living are more affordable in Sacramento and its surrounding suburbs than in most other neighboring areas in the North Bay, making Sacramento one of the hottest housing markets in the country year after year. Augusta: JAX’s Maine Cancer Genomics Initiative (MCGI) is located in Augusta, Maine, in the Harold Alfond Center for Cancer Care (HACCC), at Maine General Hospital. It began operations in 2016 with three overarching goals: to provide cancer genomic testing for Maine cancer patients; to develop and deliver physician education about clinical genomic cancer diagnostics; and to build a network in Maine of oncology practices conducting studies in genomic medicine.