What are the responsibilities and job description for the Postdoctoral Fellow position at The McLean Hospital Corporation?
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Job Summary
We are seeking a highly motivated Postdoctoral Fellow to join our research program focused on the role of regulatory T cells (Tregs) in improving outcomes in cell replacement therapy for neurodegenerative disease. The successful candidate will lead studies aimed at defining how Tregs modulate immune responses associated with transplantation and how they may enhance graft survival and function.
The postdoctoral fellow will investigate the immunosuppressive activity of Tregs, including their capacity to regulate host inflammatory responses before and after transplantation. A major emphasis of the project will be to understand the mechanisms that influence Treg survival, persistence, and function post-transplantation. The fellow will also study approaches to mitigate the pro-inflammatory response associated with needle trauma, a key barrier to successful cell delivery and engraftment.
In addition, the candidate will explore the biology of local brain-resident or tissue-localized Tregs and their role in limiting neuroinflammation within the transplant microenvironment. This work will integrate cellular immunology, transplantation biology, and neuroinflammation, with the goal of developing strategies that improve the safety and efficacy of regenerative therapies in the central nervous system.
The ideal candidate should have a strong background in immunology, neuroimmunology, stem cell biology, transplantation biology, or a related biomedical field. Experience with T-cell biology, flow cytometry, in vitro immune assays, animal models, histology, and molecular or cellular techniques will be highly desirable. Candidates should be independent, scientifically rigorous, and enthusiastic about working in an interdisciplinary and translational research environment.
This position offers the opportunity to contribute to a growing area of investigation at the interface of immunology, neuroscience, and regenerative medicine, with strong potential for high-impact publications and translational relevance.
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