Scientist I

Role: Scientist I

Location: San Carlos, CA/Onsite

Pay: $62-$68/hr.

The Analytical Scientist I will assume a critical role of development and executing the key analytical methods to support the measurement of titer, impurities and product quality for in process intermediates. 

Essential Functions:

• Method Development & Optimization: Establish and optimize analytical methods for biologics, including HPLC (SEC, IEX/AEX), GFP assays, and protein quantification.
  
• High-Throughput Automation: Design and implement automated workflows using liquid handling and robotic platforms (e.g., Tecan, Big Tuna) to enable high-throughput sample processing and buffer exchange.
  
• Data Analysis & Interpretation: Acquire and interpret complex data sets for lysate activity and protein characterization; provide actionable insights for process development studies.
  
• Laboratory Execution: Perform precise sample preparation and plate-based assays with a focus on high accuracy and low %CV.
  
• Collaborative Design: Partner with cross-functional SMEs to design experiments, troubleshoot instrumentation, and advance novel analytical techniques.
  
• Reporting & Documentation: Maintain rigorous documentation in Electronic Lab Notebooks (ELNs) such as Benchling; present data-driven results at group meetings and contribute to technical reports.
  
• Project Ownership: Work independently to manage assigned tasks, from initial method development through to routine sample testing and troubleshooting
  
  

Requirements:

• Education: PhD with 1-2 yrs experience, or B.S in Chemistry, Analytical Chemistry, Biochemistry, or related field with minimum 8 years relevant industry experience; MS with minimum 5 years of industry experience.
  
• Technical Proficiency: Extensive hands-on experience with AEX/SEC-HPLC, GFP assays, and automated platforms like Big Tuna.
  
• Analytical Rigor: Demonstrated ability to perform reliable data analysis and interpret results within the context of process characterization and regulatory guidelines.
  
• Problem Solving: Strong critical thinking skills with a proven track record of troubleshooting complex instrumentation and assay variations.
  
  
  

Soft Skills:

• A proactive team player with excellent communication skills and the ability to thrive in a fast- paced, collaborative laboratory environment.
  
• Innovation: A natural curiosity for applying new technologies and scientific creativity to solve complex analytical challenges.
  
  
  

Reports to: Staff Scientist, Downstream Development for Protein Development and Manufacturing