What are the responsibilities and job description for the Manager, Clinical Sciences position at tangotherapeutics?
Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts
Summary
Tango has an exciting opportunity to join the team as Manager, Clinical Sciences. In this role, you will support the development, planning, execution, and evaluation of clinical studies to ensure scientific integrity and accurate interpretation of data. You will report to the Senior Medical Director, Clinical Development.
Your Role:
- Support the clinical development of investigational oncology therapies by contributing to study design discussions. This includes patient population definitions, endpoint selection, protocol feasibility assessments, and literature research of medical publications to extract data and relevant scientific information
- Partner with cross-functional teams to support the timely start-up and execution of clinical trials in accordance with regulatory requirements and Good Clinical Practice (GCP)
- Collaborate with data management, clinical operations, biostatistics, pharmacovigilance, and other clinical teams to ensure alignment on study milestones and deliverables
- Contribute to the development and review of clinical documents including protocols, informed consent forms, Investigator's Brochures, clinical study reports, and regulatory submission materials
- Assist with reviewing and writing other clinical trial documents and publications as needed
- Conduct targeted literature reviews and extract relevant data from medical publications to support clinical development strategy and regulatory submissions
- Provide clinical and scientific support to clinical sites and CROs, including assistance with protocol training, site communications, and query resolution
- Review clinical data in EDC systems including data cleaning, to identify safety signals and trends, summarize findings, and contribute to interim data reviews and study decision making
- Collaborate with data management to develop and maintain clinical data review plans, including defining data review schedules, identifying critical data points for monitoring, and establishing processes for ongoing data quality oversight
- Prepare clear, concise data summaries and study status updates for internal team meetings and cross-functional review
- Perform other related duties and responsibilities as assigned
What You Bring:
- MS, PharmD, PhD, RN, or PA degree in a relevant scientific or clinical discipline
- At least 5 years’ experience in clinical science, or research
- At least 2 years’ experience in oncology
- Understanding of clinical trial design, regulatory guidelines (FDA/ICH), and GCP principles
- Strong analytical skills with proficiency in interpretation of clinical data and identification of clinical trends
- Excellent written and oral communication skills, with the ability to convey complex scientific concepts clearly
- Proven success operating in a high pace, dynamic team setting
- Collaborative mindset with eagerness to learn and grow within clinical development
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.