What are the responsibilities and job description for the Lead System Engineer position at System One?
Title: Lead Design Engineer
Location: Onsite, Pittsburgh, PA 15213
Type: 6-month contract to hire
Hours: Standard business hours
Overview: Join a cutting-edge lab to discover novel therapeutics that are seeking a highly motivated Lead Engineer to support the development, integration, and operation of advanced aerosol delivery, sensing, and exposure systems for human-relevant experimental platforms. This role focuses on ensuring precise, reproducible generation and delivery of airborne agents, as well as integration of instrumentation and multi-system platforms to enable controlled and standardized experimental workflows. The position will contribute to system optimization, performance validation, and operational readiness in complex laboratory environments.
Responsibilities:
- Design, prototype, and refine biomedical devices and components supporting advanced experimental system
- Develop and optimize fabrication processes to ensure consistency, quality, and scalability
- Contribute to selection and evaluation of materials, fabrication methods, and assembly workflows
- Perform testing and validation of device performance, including durability, reproducibility, and functional integrity
- Collaborate with scientific and engineering teams to align device design with experimental requirements
- Maintain documentation related to design iterations, fabrication processes, and quality control
- Troubleshoot device-related issues and implement design improvements
- Support coordination of engineering activities across multidisciplinary teams and contribute to project execution
- Contribute to preparation of technical documentation, reports, and related materials
Requirements:
- Bachelor’s degree in Biomedical Engineering, Mechanical Engineering, Electrical / System Engineering, or a related field
- Minimum of 3 years of relevant experience in device design, prototyping, or fabrication
- Experience with engineering design tools (e.g., CAD software)
- Strong problem-solving skills and attention to detail
- Ability to work effectively in multidisciplinary research and engineering environments
Preferred Qualifications
- Master’s or Ph.D. in a relevant engineering discipline
- Experience with fabrication of small-scale or precision-engineered devices, including Organs-on-Chips, injection molding, and CNC milling
- Familiarity with polymer-based materials and manufacturing processes
- Experience with iterative prototyping and design-for-manufacturing principles
- Experience working at the interface of engineering and biological systems
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