What are the responsibilities and job description for the Lead Integration Engineer position at System One?
Title: Lead Integration Engineer
Location: Onsite, Pittsburgh, PA 15213
Type: Direct-Hire/Permanent
Hours: Standard business hours
Overview: Join a cutting-edge lab to discover novel therapeutics that are seeking a highly motivated Lead Engineer to support the integration, optimization, and operation of complex fluidic and instrumentation systems for advanced human-relevant experimental platforms. This role focuses on system-level design and implementation of fluid handling architectures, ensuring reliable, reproducible, and physiologically relevant operation across single- and multi-component platforms. The position will contribute to development of robust, scalable systems that integrate mechanical, fluidic, and control elements to support standardized experimental workflows.
Responsibilities:
- Design, develop, and optimize fluidic systems, including manifolds, tubing layouts, and pump-controlled flow networks
- Implement stable, leak-free circulation systems with controlled and reproducible flow profiles across experimental platforms
- Support development of physiologically relevant flow conditions, including continuous and directional flow regimes
- Integrate fluidic systems with broader experimental platforms, including device interfaces, instrumentation, and control systems
- Contribute to system-level architecture design, coordinating fluidic, mechanical, and sensing components
- Develop and implement control strategies for pumps, valves, and fluid routing systems
- Perform system testing, validation, and troubleshooting to ensure operational reliability and consistency
- Maintain detailed documentation of system configurations, standard operating procedures (SOPs), and performance validation
- Collaborate with multidisciplinary teams to align system functionality with experimental and operational requirements
- Contribute to improvement of system robustness, usability, and scalability for sustained and repeatable operation
Requirements:
- Bachelor’s degree in Mechanical Engineering, Electrical / Systems Engineering, or a related field
- Minimum of 3 years of relevant experience in fluid systems, instrumentation, or experimental platform development
- Experience with fluid handling systems, pumps, tubing, or flow control architectures
- Experience with system integration and hardware-based experimental platforms
- Strong analytical, troubleshooting, and problem-solving skills
- Ability to work effectively in multidisciplinary research and engineering environments
Preferred Qualifications
- Master’s or Ph.D. in a relevant engineering discipline
- Experience with microfluidics, perfusion systems, or biologically relevant flow systems
- Familiarity with control systems, sensors, and automated or semi-automated fluid handling platforms
- Experience with design and implementation of complex, multi-component systems
- Experience with data acquisition, monitoring systems, or system diagnostics
- Experience working at the interface of engineering and biological systems
- Experience in controlled or regulated laboratory environments
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Ref: #558-Scientific