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Manager, SOX Compliance and Technical Accounting

Summit Therapeutics, Inc.
Menlo Park, CA Full Time
POSTED ON 1/5/2026
AVAILABLE BEFORE 2/9/2026
Location: Menlo Park, CA / Princeton, NJ / Miami, FL ONSITE

About Summit

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.

Summit’s Team Is Inspired To Touch And Help Change Lives Through Summit’s Clinical Studies In The Field Of Oncology. Summit Has Multiple Global Phase 3 Clinical Studies, Including

Non-small Cell Lung Cancer (NSCLC)

  • HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.
  • HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.
  • HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC)

  • HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.

Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview Of Role

The Manager, SOX Compliance and Technical Accounting will be responsible for Ongoing SOX compliance and be involved in complex accounting transactions including accruals, collaboration accounting, and other technical areas. This role will report to the Associate Director, SEC Reporting & Tech Accounting.

Role And Responsibilities

  • Lead the company’s SOX 404 implementation program (under COSO framework), including scoping, risk assessment, control design, testing, and remediation.
  • Develop and maintain an inventory of key controls in a Risk and Control Matrix (RCM), which includes the mapping of controls to the relevant financial statement line items, control type (manual vs. IT), and frequency of the control (daily, weekly, etc.).
  • Maintain comprehensive controls documentation, including narratives, flowcharts, and risk/control matrices.
  • Partner with IT, FP&A, and Clinical teams to develop and monitor automated controls and system dependencies that are well-designed and documented. Serve as a trusted advisor on IT general controls for these groups.
  • Liaise with internal and external auditors and coordinate SOX scoping, testing, and remediation of findings.
  • Serve as a bridge between Finance/Accounting team and Internal and external auditors to coordinate audit timelines and scope.
  • Serve as the central point of contact for all SOX audit requests from internal and external auditors and manage the process for timely completion of audit.
  • Partner cross-functionally to develop and strengthen appropriate entity-level controls, business process (manual & automated) controls, incident reporting frameworks, and reporting structures expected of a public company.
  • Evaluate and strengthen controls over system access, change management, and data integrity for all in-scope systems.
  • Drive annual and quarterly SOX risk assessments, and the controls certification process.
  • Prepare reports and updates for the Audit Committee, external auditors, and executive leadership.
  • Serve as the trusted advisor to business leaders on internal controls, risk management, and compliance trade-offs.
  • Provide controls advisory on transformation initiatives, including system implementations, process redesigns, and M&A integrations.
  • Report control effectiveness and gaps to senior stakeholders, including executive-level presentation on project findings and recommendations.
  • Educate stakeholders on control requirements and best practices including developing checklists, design, testing attributes etc.
  • Research, document memos, record, and communicate technical accounting matters as they arise and journal entries for complex accounting transactions
  • Analyze and interpret new accounting standards and SEC regulations, research and provide appropriate accounting guidance related to various business transactions
  • Research new disclosures and FASB accounting standards updates and work with external auditors on appropriate disclosure requirements
  • Develop, create and/or modify the company’s financial accounting policies and procedures to ensure that the policies and procedures are in accordance with U.S. GAAP
  • Complete special projects as assigned.
  • All other duties as assigned.

Experience, Education And Specialized Knowledge And Skills

  • Bachelor’s degree in Accounting, Finance, Business Administration, or a related field required
  • CPA, CIA, or CISA certification strongly preferred
  • Minimum of 5 years of experience in internal controls, SOX compliance, and audit
  • Experience working at a public company, with a quarterly reporting cadence, is preferred
  • Good technical knowledge of US GAAP, internal controls
  • Big-4 public accounting & audit firm background strongly preferred
  • Proven track record of implementing scalable automated controls across financial systems
  • Excellent communication and stakeholder management skills, with the ability to collaborate effectively with employees, internal teams and external partners
  • Strong analytical and problem-solving skills to identify risks, conduct audits, and implement solutions
  • Results-oriented, strong organizational skills, and time management skills with ability to multi-task
  • A team player willing to step in and help with other areas of accounting
  • Excellent analytical, interpersonal, verbal, and written communication skills
  • Superb analytical, strategic, and critical thinking skills, with impeccable attention to detail, and strong prioritization and problem-solving skills
  • Demonstrated ability to operate in a fast-paced environment

The pay range for this role is $140,000-$160,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.

Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.

Salary : $140,000 - $160,000

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