What are the responsibilities and job description for the Sr Director, Medical Affairs (Obesity and Metabolic Programs) position at Structure Therapeutics?
Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.
Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.
Position Summary
Reporting to the Executive Director, Medical Affairs & Advocacy Engagement, the Sr Director, Medical Director at Structure Therapeutics will lead the development and execution of the Medical Strategy, gathering and synthesizing external insights—including treatment patterns, unmet medical needs, and competitive intelligence— across all metabolic programs.
This role is critical in shaping scientific engagement and communications, identifying evidence gaps, and supporting lifecycle management. The individual will serve as a key scientific expert internally and externally, ensuring alignment across clinical development, regulatory, and commercial readiness efforts.
As a trusted scientific partner, the Medical Director builds and sustains relationships with key opinion leaders, investigators, healthcare professionals, and patient communities, facilitating the exchange of scientific information related to the company’s pipeline and therapeutic focus areas. The role requires a high level of expertise in interpreting and communicating clinical and translational data, particularly in fast-evolving therapeutic landscapes.
The Medical Director plays a pivotal role in supporting clinical development programs by identifying and engaging top investigators and providing key insights that inform study design and execution.
Job Responsibilities
Medical Strategy
Education
Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $260,000-$360,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience. Position can be ONSITE or REMOTE.
At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.
Notice to Recruiters/Staffing Agencies
Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.
We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.
Structure Therapeutics’ receipt or acceptance of an unsolicited resume submitted by a vendor organization to this website or employee does not constitute an actual or implied contract between Structure Therapeutics and such organization and will be considered unsolicited and Structure Therapeutics will not be responsible for related fees.
Fraud Alert
To all candidates: your personal information and online safety are a top priority for us. At Structure Therapeutics, direct candidates to apply through our official career page at BambooHR.
Recruiters will always contact you using the domain of Structuretx.com. We will never request payments, ask for financial account information or sensitive information like social security numbers. If you are unsure if a message is from Structure Therapeutics, please email human resources.
Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.
Position Summary
Reporting to the Executive Director, Medical Affairs & Advocacy Engagement, the Sr Director, Medical Director at Structure Therapeutics will lead the development and execution of the Medical Strategy, gathering and synthesizing external insights—including treatment patterns, unmet medical needs, and competitive intelligence— across all metabolic programs.
This role is critical in shaping scientific engagement and communications, identifying evidence gaps, and supporting lifecycle management. The individual will serve as a key scientific expert internally and externally, ensuring alignment across clinical development, regulatory, and commercial readiness efforts.
As a trusted scientific partner, the Medical Director builds and sustains relationships with key opinion leaders, investigators, healthcare professionals, and patient communities, facilitating the exchange of scientific information related to the company’s pipeline and therapeutic focus areas. The role requires a high level of expertise in interpreting and communicating clinical and translational data, particularly in fast-evolving therapeutic landscapes.
The Medical Director plays a pivotal role in supporting clinical development programs by identifying and engaging top investigators and providing key insights that inform study design and execution.
Job Responsibilities
Medical Strategy
- Develop and execute a comprehensive Medical Strategic Plan, including insight generation, data dissemination, and medical communications, across all obesity and related metabolic programs
- Lead Publication Strategy across all programs (abstracts, manuscripts, congress presentations)
- Build relationships with Key Opinion Leaders (KOLs), academic institutions, and healthcare providers
- Present clinical and scientific data on metabolic therapies. Represent the company at medical and community congresses, advisory boards
- Lead high-level scientific discussions on disease state and treatment landscape
- Support Investigator-Initiated Trials (IITs) and real-world evidence studies
- Gather and synthesize medical insights from HCP interactions
- Inform clinical development plans and lifecycle management
- Partner with:
- Clinical development (trial design considerations, medical insights, unmet medical need)
- Clinical Operations (investigator needs and engagement)
- Market access (value messaging)
- Commercial teams (compliant scientific support)
- Review materials for scientific accuracy and compliance as representative in Medical Legal Regulatory (MLR) review process
- Ensure all activities comply with regulatory and ethical standards
Education
- MD, PharmD, or PhD in a relevant scientific field
- 10 years in biotech/pharma
- Strong background in metabolic diseases (e.g., obesity, type 2 diabetes), global experience a plus
- Prior experience as Medical Director or equivalent in Medical Affairs
- Deep scientific expertise in metabolism. Direct experience in obesity, type 2 diabetes, or incretin-based therapies is preferred
- Experience with protocol design in metabolism, particularly incretin therapies
- Strong communication and presentation skills
- Leadership and team management ability
- Strategic thinking with execution focus
- Regional or national coverage
- Travel (25%) for HCP engagement and conferences, corporate meetings
Structure Therapeutics is committed to fair and equitable compensation practices, and we strive to provide employees with total compensation packages that are market competitive. For this role, the anticipated base pay range is $260,000-$360,000. The exact base pay offered for this role will depend on various factors, including but not limited to the candidate’s geography, qualifications, skills, and experience. Position can be ONSITE or REMOTE.
At Structure, base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus, new hire equity, and ongoing performance-based equity. Structure Therapeutics also offers various benefits offerings, including, but not limited to, medical, dental, and vision insurance, 401k match, unlimited PTO, and a number of paid holidays including winter shutdown.
Notice to Recruiters/Staffing Agencies
Recruiters and staffing agencies should not contact Structure Therapeutics through this page. All recruitment vendors (search firms, recruitment agencies, and staffing companies) are prohibited from contacting our hiring manager(s), executive team members, or employees.
We require that all recruiters and staffing agencies have a fully executed, formal written agreement on file.
Structure Therapeutics’ receipt or acceptance of an unsolicited resume submitted by a vendor organization to this website or employee does not constitute an actual or implied contract between Structure Therapeutics and such organization and will be considered unsolicited and Structure Therapeutics will not be responsible for related fees.
Fraud Alert
To all candidates: your personal information and online safety are a top priority for us. At Structure Therapeutics, direct candidates to apply through our official career page at BambooHR.
Recruiters will always contact you using the domain of Structuretx.com. We will never request payments, ask for financial account information or sensitive information like social security numbers. If you are unsure if a message is from Structure Therapeutics, please email human resources.
Salary : $260,000 - $360,000