What are the responsibilities and job description for the Scientist / Senior Scientist, Analytical Development position at Strand Therapeutics?
Company Overview:
Strand Therapeutics is a clinical stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies to patients.
Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological engineers working together at MIT who were seeking to apply the concept of the emerging field of mRNA therapeutics. Strand's technology is therapeutic-area and mRNA modality agnostic where therapeutic proteins are encoded onto modified, self-replicating, or circular mRNA backbones which in turn are programmed with cell-specific sensors and circuits.
Today, Strand has established three platforms with one clinical stage asset and several programs in preclinical development as well as early discovery. Our lead program, STX-001, is currently being evaluated in a phase 1 clinical trial for solid tumors. Our corporate headquarters is located in the Fenway district of Boston, Massachusetts.
Become the next standout single strand!
Job Summary:
Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.
We are looking for a highly motivated and innovative candidate for the role of Scientist / Senior Scientist of Analytical Development. The expectation is that the Scientist / Senior Scientist will have experience independently executing analytical experiments using HPLC/UPLC techniques. Reporting to the Associate Director of Analytical Development, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for Strand along with a desire to conquer new challenges.
Primary Responsibilities:
Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.
Job Type: Full-time
Salary: $120,000 - $142,000 annually plus bonus and equity incentives
Pay Transparency Base Salary Range
$120,000—$142,000 USD
Strand Therapeutics is a clinical stage biotechnology company utilizing synthetic biology to genetically program mRNA to deliver truly revolutionary immunotherapies to patients.
Building on the idea of creating smart therapies based on Boolean logic circuits, Strand was started by biological engineers working together at MIT who were seeking to apply the concept of the emerging field of mRNA therapeutics. Strand's technology is therapeutic-area and mRNA modality agnostic where therapeutic proteins are encoded onto modified, self-replicating, or circular mRNA backbones which in turn are programmed with cell-specific sensors and circuits.
Today, Strand has established three platforms with one clinical stage asset and several programs in preclinical development as well as early discovery. Our lead program, STX-001, is currently being evaluated in a phase 1 clinical trial for solid tumors. Our corporate headquarters is located in the Fenway district of Boston, Massachusetts.
Become the next standout single strand!
Job Summary:
Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company.
We are looking for a highly motivated and innovative candidate for the role of Scientist / Senior Scientist of Analytical Development. The expectation is that the Scientist / Senior Scientist will have experience independently executing analytical experiments using HPLC/UPLC techniques. Reporting to the Associate Director of Analytical Development, the right candidate will be a strategic thinker that brings a leadership presence and enthusiasm for Strand along with a desire to conquer new challenges.
Primary Responsibilities:
- Leads development, execution, and validation of RP-IP/RP/IEX based analytical methods to establish identity, purity, potency, and stability criteria for early-stage mRNA and LNP formulations using UPLC-ESI-ToF, PDA, and CAD.
- Analyzes data and draws conclusions which drive screening, optimization, and scale-up efforts in mRNA and LNP Process Development.
- Serves as subject matter expert in analytical chemistry, mass spectrometry, and method qualification and transfer.
- Interfaces with external contract research organizations to ensure compliance with internal timeline and quality requirements.
- Mentors and develops junior scientists in analytical theory and in applications of analytical technology and software platforms.
- Created proprietary ToF mass spec oligonucleotide mass target and predictive sequence library software to rapidly profile known and identify unknown oligonucleotide mass signals.
- Maintains electronic notebook records and authors protocols.
- Contributes to data packages for regulatory submissions.
- Actively maintains current understanding of RNA and LNP landscape by attending conferences and other events.
- B.S. or Advanced Degree in Chemistry, Chemical Engineering, Biology, Biochemistry, Molecular Biology or other relevant scientific discipline.
- 7 years of experience with a focus on varying liquid chromatography modes (RP, RP-IP, AEX, SEC, etc), LC-MS, or capillary gel electrophoresis.
- Working experience in HPLC/UPLC method development.
- Experience with enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for biologics or nucleic acid therapies.
- This position requires conducting laboratory experiments, excellent documentation review and writing skills, and the flexibility to work on multiple projects as needed.
- Understanding of process development, and/or regulatory aspects of mRNA-(lipid) nanoparticle products would be a plus.
- Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.
- A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently.
- Independently motivated, detail oriented and good problem-solving ability.
Strand Therapeutics is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law. Strand does not accept unsolicited resumes from any source other than directly from candidates.
Job Type: Full-time
Salary: $120,000 - $142,000 annually plus bonus and equity incentives
Pay Transparency Base Salary Range
$120,000—$142,000 USD
Salary : $120,000 - $142,000