Accounting Manager

Souffle Therapeutics | Accounting Manager | Job Description

Souffle Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It’s team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest!

SUMMARY

We are seeking a hands-on Accounting Manager to build and scale our growing accounting function as we look ahead in the next few years. This role will oversee core general accounting activities and be critical in establishing accounting processes for clinical operations, R&D accounting, ensuring GAAP compliance, and preparing the company for future growth, financing events, and audit readiness.

The ideal candidate thrives in a fast-paced, evolving environment and brings both strong technical accounting expertise and a proactive, process-building mindset.

Key Responsibilities

Accounting Operations & Close

• Oversee and perform day-to-day accounting activities, including journal entries, reconciliations, accounts payable, purchase orders, and general ledger maintenance. Play a key role in preparing the company for future financing events and public company readiness.
• Lead and execute month-end and quarter -end close processes, ensuring timely and accurate financial reporting and continual improvement of close efficiency and scalability
• Review accounting work prepared by junior staff or external partners, providing guidance and quality control as needed.
• Maintain fixed asset, lease, prepaid, and other sub-ledger schedules in accordance with U.S. GAAP.
• Prepare and manage accruals related to research, clinical, and operational activities, including CROs, vendors, and interdepartmental expenses.
• Partner closely with R&D, Clinical Operations, and FP&A teams to track project costs and ensure proper accounting treatment of research activities.
• Support accounting for research-related expenditures, including vendor accruals and project-based spend.

Financial Reporting & Compliance

• Prepare and analyze financial statements, management reports, and supporting schedules.
• Ensure compliance with U.S. GAAP, internal controls, and company accounting policies.
• Deliver timely and accurate reporting for internal stakeholders, investors, and the Board
• Assist in developing, documenting, and maintaining SOX ready accounting policies and procedures designed to scale with a growing organization.

Audit, Systems & Process Improvement

• Support external audits and serve as a key liaison with auditors by preparing schedules and responding to inquiries.
• Assist with the optimization of ERP and finance systems (e.g., NetSuite) and related reporting tools.
• Continuously assess accounting processes and controls to identify opportunities for increased efficiency, accuracy, and scalability.
• Leadership & Collaboration
• Provide day-to-day guidance and mentorship to junior accounting staff or contractors, as applicable.
• Act as a collaborative partner across finance and operational teams, contributing to a strong control environment and continuous improvement mindset.
• Responsibilities may evolve over time based on organizational priorities and growth stage.

Qualifications

• 3–5 years of accounting experience, with 1–2 years in a lead or early manager capacity
• Public accounting experience and industry experience within biotech, life sciences, or a regulated R&D environment required.
• Demonstrated public company experience
• Hands-on experience with month-end close, reconciliations, and preparation of financial statements.
• Working knowledge of U.S. GAAP and financial reporting requirements.
• Experience with ERP/accounting systems (e.g., NetSuite ideal).
• Strong Excel skills and comfort working with large data sets and schedules.
• Fluency with use of AI models/technology to support the finance operations” something just to include knowledge/comfort with using AI

Education

• Bachelor’s degree in accounting, Finance, or related field
• CPA required

At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. This is an onsite position in Watertown, MA with flexibility as needed for collaboration and external engagements.