Scientist I/II, Gene Therapy Drug Discovery

Scientist I/II – Gene Therapy Drug Discovery Biologist – Solid Biosciences

Charlestown, MA

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care.

Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases.

We are seeking a highly skilled and motivated bench scientist to join the Molecular Therapeutics team to select our lead therapeutics. The ideal candidate will have a strong scientific background in human iPSC biology, animal husbandry, in vivo biodistribution studies (small and large animal), protein science, molecular biology, and quantitative imaging techniques.

Key Position Responsibilities

• Contribute to both the inception and selection of AAV libraries
• Optimize in vitro and in vivo models to select lead therapeutics for translation to humans
• Design and manage animal studies at contract vivariums and CROs
• Quantitatively compare VG, mRNA, and protein levels in cells and tissues
• Detailed understanding of antibody and FISH imaging techniques to quantify biodistribution and expression levels
• Collaborate within the MTx Department and across the R&D organization to incorporate selected therapies into the Discovery & Translational Development pipeline
• Communicate findings and insights to stakeholders through presentations, patents, publications, and scientific conferences
  
  

Experience Requirements

• PhD in Physiology, Pharmacology, Virology, or another related discipline and 0-4 years of relevant experience preferred
• Or: MS and 6-8 years of relevant experience; BS and 8-10 years of relevant experience
• Strong track record in experimental design, animal husbandry, molecular genetics and cellular biology, statistics, protein science, and imaging
• Proficient in methods for quantitative analysis of nucleic acid and protein including nucleic acid extraction, ddPCR, ELISA, and MSD
• Familiarity with lab automation systems is a plus
• Hands-on experience with performing dosing and tissue collection procedures with mouse models is desirable
• Proficiency in computing include Geneious, Endnote, BLAST, Ensembl, NCBI, Uniprot, UCSC, GTEx, Microsoft, PRISM statistics program, Benchling
• Strong problem-solving skills and the ability to work independently and collaboratively
• Excellent communication and presentation skills
  

Compensation

The base compensation range for this role is: $125,000 - $155,000

Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.

Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance.

Benefits And Solid Advantages

At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees’ lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices.

• Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
• 401(k) program participation with competitive company matched contributions
• Eligibility to participate in Solid’s Employee Stock Purchase Plan
• Mobile phone subsidy for eligible employees
• Tuition Reimbursement
• Vision Coverage
• Life Insurance
• Voluntary Pet Insurance
• Employee Discount Program on Travel, Entertainment, and Services
• Employee Assistance Programs
• Daily Subsidized Lunch Delivery (onsite @ Hood Park)
• Free Onsite Full-Service Gym (onsite @ Hood Park)
• Employee Parking (onsite @ Hood Park)
• 12 Observed Holidays and a winter shut down
• 15-day PTO Policy and an 80-hour rollover YoY
• 40-hour Sick Policy
• 8 Hour Floating Holiday