Laboratory Operations & Facilities Manager

Role Overview

SiPhox is seeking a Laboratory Operations & Facilities Manager to own the day-to-day execution, safety, and reliability of our BSL-2 laboratory and associated facilities. This is a hands-on role at the intersection of laboratory operations, biosafety, facilities management, and regulatory compliance.

You will be responsible for ensuring that laboratory and facility systems operate safely, efficiently, and in full compliance with regulatory and quality requirements. This includes laboratory equipment lifecycle management, biosafety and chemical safety programs, facility infrastructure, environmental controls, vendor coordination, audits, and future facility changes or relocations.

The ideal candidate combines deep operational rigor, strong biosafety instincts, and a pragmatic, sleeves-rolled-up mindset. You are comfortable leading through complexity, responding to urgent issues, and supporting scientists and engineers in a fast-moving diagnostic development environment.

Key Responsibilities

Laboratory Operations

• Own day-to-day laboratory operations for a BSL-2 environment, ensuring uninterrupted, compliant, and safe execution of diagnostic and R&D activities.
• Manage the full lifecycle of laboratory equipment, including procurement, installation, qualification (IQ/OQ/PQ as applicable), calibration, maintenance, and decommissioning.
• Oversee laboratory inventory, consumables, reagents, and supplies, maintaining appropriate stock levels and traceability.
• Ensure proper handling, storage, and disposal of diagnostic samples, biohazardous materials, and chemicals in accordance with all standards and regulations.
• Maintain and improve laboratory SOPs, work instructions, and operational documentation in collaboration with Quality Assurance.
• Support laboratory IT and data systems, including LIMS, equipment software, and data management tools, to enable efficient and compliant lab workflows.
• Manage laboratory budgets, purchasing, service contracts, and vendor relationships for critical equipment and environmental systems.

Facilities Management

• Own facility operations supporting the laboratory, including HVAC, electrical, plumbing, environmental monitoring, access control, and security systems.
• Serve as the primary point of contact and first responder for facility issues, ranging from routine maintenance to urgent incidents (e.g., power outages, alarms, system failures).
• Coordinate and oversee external vendors and contractors for maintenance, repairs, inspections, and renovations.
• Manage internal equipment moves, space planning, and lab reconfigurations as needs evolve.
• Oversee logistics for incoming and outgoing shipments, including temperature-sensitive or regulated materials.
• Support planning and execution of future facility expansions or relocations as the company grows.

Biosafety, EHS, and Regulatory Compliance

• Own BSL-2 biosafety compliance, including biosafety protocols, training, incident response, and continuous improvement.
• Develop, implement, and maintain laboratory safety, chemical safety, and environmental health programs.
• Ensure compliance with applicable regulations and standards, including FDA, ISO, local/state requirements, and City of Burlington regulations.
• Prepare for and participate in internal audits, external inspections, and regulatory reviews.
• Partner closely with Quality Assurance and Regulatory Affairs to support documentation, inspections, and corrective actions.

Leadership & Stakeholder Management

• Act as a trusted operational partner to scientists, engineers, and leadership, enabling safe and efficient lab execution.
• Lead by example with a service-oriented mindset—no task is too big or too small when it comes to safety and uptime.
• Provide clear, proactive communication to leadership regarding operational status, risks, incidents, and improvement initiatives.
• Build strong working relationships with regulators, inspectors, vendors, and service providers.
• Organize and prioritize work effectively in a dynamic, startup environment with shifting priorities.
• Communicate clearly across multiple formats, including written reports, SOPs, presentations, email, messaging tools, and in-person discussions.

Qualifications

Required / Strongly Preferred

• 5 years of experience managing laboratory operations in a BSL-2 environment, including hands-on responsibility for biosafety and environmental controls.
• Demonstrated experience in diagnostic, clinical, or regulated laboratory operations.
• Formal training in biosafety, laboratory safety, or environmental health and safety.
• Working knowledge of FDA regulations, ISO standards (e.g., ISO 13485), and quality management systems.
• Proven ability to operate independently, troubleshoot issues, and address hands-on facility or equipment needs without relying exclusively on external support.
• Strong organizational skills, attention to detail, and ability to manage multiple priorities simultaneously.
• Excellent written and verbal communication skills with the ability to collaborate cross-functionally.

Highly Desirable

• Experience establishing or scaling a laboratory from the ground up.
• Experience with laboratory IT systems, LIMS, equipment software, and data infrastructure.
• Technical aptitude in electrical, mechanical, or photonics-adjacent systems; ability to troubleshoot lab instrumentation is a strong plus.
• Prior experience supporting audits, inspections, or regulatory submissions.
• Background demonstrating physical readiness and situational awareness for operational roles requiring on-site response and hands-on problem solving.

Education

• Bachelor’s degree or higher in Microbiology, Biochemistry, Biomedical Engineering, Electrical Engineering, or a related field preferred.

About SiPhox

SiPhox Health is creating an entirely new category of at-home technology that brings advanced biological measurement into everyday life. Our platform brings together silicon photonics, microfluidics, motion systems, sensing, thermal control, and embedded computing inside a compact device that performs complex biochemical analysis in minutes. We are building a consumer product that has never existed before. It integrates optics, chemistry, mechanics, biology and electronics into a seamless experience designed for millions of homes.

We offer competitive benefits, including a Life Time Fitness membership and the opportunity to work in a fast-paced, mission-driven environment building the future of home health.