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Postdoctoral Fellow – GPCR Signaling and Rare Disease Mechanisms

Sanford Health
Sanford Health Salary
Sioux, SD Full Time
POSTED ON 8/30/2026
AVAILABLE BEFORE 9/29/2026
**Careers With Purpose** **Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland.** **Facility:** Sanford Center Building **Location:** Sioux Falls, SD **Address:** 2301 East 60th St N, Sioux Falls, SD 57104, USA **Shift:** 8 Hours - Day Shifts **Job Schedule:** Full time **Weekly Hours:** 40.00 **Department Details** The Masuho Lab studies the molecular and cellular mechanisms of G protein-coupled receptor (GPCR) signaling, with a focus on how GPCRs and related signaling molecules contribute to human disease. GPCRs are the largest class of cell-surface receptors and are major targets for therapeutic drugs. This postdoctoral position will focus on understanding GPCR signaling mechanisms and disease-associated variants using cell-based functional assays, including BRET-based G protein activation assays, receptor expression assays, and related molecular and cellular approaches. The overall goal is to define how altered GPCR signaling contributes to disease and to use these insights to guide mechanism-based therapeutic strategies **Job Summary** Post Doctoral Fellow will perform independent scientific research including complex laboratory testing, experiments and analysis following established protocols. Designs and develops research objectives for experimentation. Analyzes and evaluates findings. Assists in completion of grant applications and other regulatory documents. Writes technical summaries and co-authors articles for publication. Prepares and makes formal presentations of research results. Typically works under broad direction of principal investigator. High level of knowledge in scientific research processes, procedures, and objectives. Possesses ability to implement experiments in the subject discipline with the ability to trouble shoot issues. Good knowledge of the principles and techniques of the subject discipline required. Teach principles and techniques of medical and laboratory procedures to junior individuals working in the lab. Possesses ability to run complex pieces of equipment requiring advanced specialized training. Possesses knowledge of modern research methods, data collection and analysis. Significant experience in analyzing and evaluating data. General level of knowledge of project management, decision-making, and analytical skills. Strong verbal, written, and interpersonal communication skills. Ability to work collaboratively with a research group or team. Sanford Research is a multi-site institution and occasional local travel between sites may be required. **Qualifications** Requires a doctorate degree in a clinical, health, or life science field. Management experience is highly recommended. Selected from national applicant pool or known to be nationally competitive. **Benefits** Sanford offers an attractive benefits package for qualifying full-time and part-time employees. Depending on eligibility, a variety of benefits include health insurance, dental insurance, vision insurance, life insurance, a 401(k) retirement plan, work/life balance benefits, and a generous time off package to maintain a healthy home-work balance. For more information about Total Rewards, visit https://sanfordcareers.com/benefits . Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org . Sanford has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment. **Req Number:** R-0266138 **Job Function:** Research **Featured:** No

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