Sr Research Associate/Associate Scientist, Discovery Biology

SanegeneBio USA

Woburn, MA

SanegeneBio is a global, venture-backed, clinical-stage biotechnology company advancing best-in-class genetic medicines. We are 90 employees with a single vision: unlocking the full potential of RNAi-powered medicines. With our corporate headquarters and platform research center in the Boston area, as well as R&D and clinical operations in China, SanegeneBio is well-positioned to develop innovative oligonucleotide therapeutics and improve patient outcomes. Our LEAD™ siRNA delivery and chemistry platform enables systemic delivery to tissues and cell types of therapeutic relevance with a strong selectivity, tolerability, potency, and duration of action profile. Our Core Values foster cross-functional collaboration, continuous learning, scientific rigor, and an enduring spirit of optimism.

SanegeneBio is currently seeking a Sr. Research Associate/Associate Scientist:

We are seeking a motivated Sr. Research Associate/Associate Scientist (title dependent on prior experience and capabilities) to join our Discovery Biology team based at our Woburn R&D site. This laboratory-based role will support in vivo pharmacology and mechanistic studies to advance our oligonucleotide therapeutics programs, working closely with cross-functional teams. This individual will support research to investigate innovative drug delivery approaches, including novel ligand/receptor approaches to achieve tissue-selective pharmacology. This is an excellent opportunity to build hands-on expertise in a structured research environment while contributing to ongoing projects.

Requirements:

• Perform and/or support complex and time-sensitive laboratory tasks under the supervision of our biology leaders; this includes in vitro assays, in vivo studies and molecular endpoints to evaluate our experimental therapeutics.
• Carefully perform laboratory work according to SOPs and protocols; participate in protocol generation and maintenance. Support generation of detailed study reports and maintain research records in an electronic notebook system according to company documentation policy.
• Perform molecular and cellular biology assays, including but not limited to nucleic acid extraction, qPCR, ELISA, and western blot.
• Implement and/or optimize analytical methods as required by project plans.
• Complete experimental tasks within timelines; accurately record, analyze, and organize experimental data.
• Operate and maintain laboratory instruments and equipment.
• Actively participate in project meetings by presenting experimental results and study proposals.

Qualifications:

• BS or MS in biology, pharmacology, or related field.
• 3-5 years relevant biopharma industry experience
• Technical expertise in subset of the following methodologies: qPCR, nucleic acid isolation, western blot, ELISA, plate-based assays, in vivo disease modeling, immunohistochemistry etc., microscopy.
• Hands-on experience with rodent pharmacology. Animal handling experience including dosing and tissue sampling methods required. Familiarity with IACUC and research animal compliance framework.
• Ability to independently read scientific literature and generate experimental ideas.
• Strong interpersonal skills and communication skills; ability to thrive in a fast-paced team environment. Excellent attention to detail and documentation skills, uncompromising in research ethics

Benefits

• Medical, dental, and vision insurance (HSA/FSA programs)
• 401(k) with company match
• Annual bonus and equity compensation