Oligonucleotide Scientist

Date Posted: 07/22/2026

Hiring Organization: Rose International

Position Number: 504540

Industry: Biotech/Healthcare

Job Title: Oligonucleotide Scientist

Job Location: South San Francisco, CA, USA, 94080

Work Model: Onsite

Shift: Shift 8 - 5 pm (Mon -Fri)

Employment Type: Temporary

FT/PT: Full-Time

Estimated Duration (In months): 4

Min Hourly Rate($): 50.00

Max Hourly Rate($): 54.00

Must Have Skills/Attributes: Biology, Chemistry, Troubleshooting

Experience Desired: Experience in oligonucleotide synthesis (3 yrs)

Required Minimum Education: Bachelor’s Degree

Preferred Education: Master’s Degree

**C2C is not available**

Education

Job Description

• BS/MS in Organic Chemistry or related discipline
  
  

Required Skills

• The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
• The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
• A good understanding of nucleic acid therapeutic modalities, modification chemistries,sequence selection, and mechanism of action is preferred.
• Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.
  
  

Preferred Skills

• Good communication and interpersonal skills are essential and will be evaluated during the interview process.
• The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.
  
  

Summary

• We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at Client.
• We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group.
• Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred.
• The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.
  
  

Responsibilities

• The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology
  
  

and oncology, to help build a comprehensive therapeutic discovery strategy.

• Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
• Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
• Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
• Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.
• **Only those lawfully authorized to work in the designated country associated with the position will be considered.**
• **Please note that all Position start dates and duration are estimates and may be reduced or lengthened based upon a client’s business needs and requirements.**
  
  

Benefits

For information and details on employment benefits offered with this position, please visit here. Should you have any questions/concerns, please contact our HR Department via our secure website.

California Pay Equity

For information and details on pay equity laws in California, please visit the State of California Department of Industrial Relations' website here.

Rose International is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender (expression or identity), national origin, arrest and conviction records, disability, veteran status or any other characteristic protected by law. Positions located in San Francisco and Los Angeles, California will be administered in accordance with their respective Fair Chance Ordinances.

If you need assistance in completing this application, or during any phase of the application, interview, hiring, or employment process, whether due to a disability or otherwise, please contact our HR Department.

Rose International has an official agreement (ID #132522), effective June 30, 2008, with the U.S. Department of Homeland Security, U.S. Citizenship and Immigration Services, Employment Verification Program (E-Verify). (Posting required by OCGA 13/10-91.).