What are the responsibilities and job description for the Solution Engineer - Diagnostics position at Roche Holdings Inc.?
At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.
The PositionWe are seeking a highly motivated Principal System Engineer I to join our End-to-End Solution Integration Chapter supporting Next-Generation Diagnostic Solutions.
In this hands-on role, you will drive feasibility, development, and integration of complex multi-disciplinary systems spanning sample preparation, library preparation, molecular detection technologies (e.g., digital PCR, sequencing by synthesis, microarray), and bioinformatics/data processing pipelines.
The Opportunity:
This role is ideal for a systems-minded engineer with direct industry experience in sequencing workflows, strong analytical and statistical skills, and the ability to influence cross-functional projects without formal people management responsibilities.
Who You Are:
You will collaborate with assay, software, hardware, and bioinformatics teams to define, integrate, and optimize system-level performance, ensuring technical robustness and operational scalability across diverse technologies.
- Drive end-to-end system development and integration across wet lab workflows, instruments, and data pipelines for next-generation diagnostic solutions.
- Perform hands-on system integration and troubleshooting of complex workflows, including molecular detection technologies and data transfer.
- Partner with assay, software, and bioinformatics teams to ensure seamless integration of sequencing output with downstream analysis pipelines.
- Apply advanced statistical analysis and Design of Experiments (DoE) methodologies (e.g., Python, JMP) to characterize, optimize, and set subsystem specifications.
- Plan, design, and execute comprehensive Verification and Validation (V&V) test cases to ensure complete requirements coverage.
- Support post-launch troubleshooting and field investigations through failure mode and root cause analyses.
- Represent Systems Engineering in cross-functional project teams and contribute to essential system documentation and continuous workflow improvement.
The expected salary range for this position is based on the primary location of California is $102,000 - $189,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are available for this position.
Who we areA healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let's build a healthier future, together.
Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Roche is an Equal Opportunity Employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.
Salary : $102,000 - $189,400