Associate II, Analytical Development

Position: FT Exempt

Location: Houston, TX (Onsite)

Department: Analytical Development

Reports to: Head of Quality Control

About CTMC 

CTMC is a pioneering biotech joint venture, formed by National Resilience and MD Anderson Cancer Center, located in the heart of the Texas Medical Center. Our mission is to accelerate cell therapies from bench to bedside. We offer a wide range of cell therapy modalities, including CAR-T, TIL, and TCR-T. Our expert team collaborates closely with MD Anderson’s research and clinical faculty, bringing impactful cell therapies to cancer patients.     

Since inception in May 2022, our team has filed eight INDs and have received approval, without delay, demonstrating our commitment to delivering innovative treatments to patients with speed and precision. Our alliance with National Resilience enables us to remain at the forefront of biomanufacturing practices, leveraging advanced technology and processes to deliver exceptional results.     

Our growing, state-of-the-art, 60,000 sq. ft. industrial facility in the Texas Medical Center is staffed by an integrated team of industry veterans and academic scientists who are passionate about bringing life-saving cures to patients. Our unique joint venture structure, with two highly established partners, provides us with the financial stability and long-term horizon to achieve our organizational goals.     

At CTMC, we value our employees and offer a variety of development opportunities within our novel corporate structure to inspire professional growth and satisfaction. We foster a team-first culture and a balanced work-life environment to ensure our staff is energized and engaged in our mission to accelerate cell therapies from bench to bedside for patients who need them. If you share our passion for advancing the frontiers of medical science with innovative therapeutics and want to join a highly dedicated team committed to delivering novel cures to patients, we invite you to submit your application. We look forward to hearing from you and exploring how your skills and expertise can help us achieve our mission. 

Responsibilities

• Participate in designing assays that assess identity, purity, and potency for cell therapy products.  
• Independently plan, organize and execute lab activities. 
• Perform analysis of experimental data, compile results and present to the team.  
• Write and revise protocols for equipment, general laboratory practices, and analytical methods. 
• Troubleshoot technical issues including planning and implementing resolutions. 
• Execute assays in accordance with established protocols and SOPs.
• Maintain accurate and timely experimental records.
• Lead technology transfer, assay qualification and validation activities.
• Maintain technical proficiency and seek new knowledge to assess novel methods as needed. 
• Responsible for monitoring inventory of supplies and ordering supplies as needed and management of laboratory upkeep and organization.
• Observe applicable safety and security procedures.
• Perform routine maintenance and calibration of AD equipment.
• Maintain knowledge of regulatory standards for analytical testing of cell therapy products.
• Train junior team members and demonstrate aptitude for managing direct reports.
• Other duties as assigned.

Qualifications/Skills

• Bachelor’s degree in a related field required.
• 1-2 yr.’s of industry related experience required, preferred in biotech manufacturing.
• Demonstrate proficiency in multiple assay areas.
• Strong hands-on experience with the following techniques is highly preferred: 
• Mammalian cell culture and aseptic techniques.
• Nucleic acid extraction and quantitation. 
• PCR, qPCR, or ddPCR assays to quantify nucleic acid abundance.
• Flow cytometry sample preparation, data acquisition, and analysis.
• ELISA assays to quantify protein abundance. 
• Handling of viral vectors, in particular retroviral and lentiviral vectors.
• Proficient with MS Office (Excel, Outlook, etc.).
• Able to work semi-independently with minimal supervision.

Working Conditions, Equipment, Physical Demands 

Physical Demands- 

• Occasional standing and walking required
• Frequent sitting, reaching, and computer/keyboard usage
• Occasional lifting, pushing, and pulling up to 10 lbs. required

The physical demands and work environment that have been described are representative of those an employee encounters while performing the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions in accordance with the Americans with Disabilities Act. 

The above job description is an overview of the functions and requirements for this position. This document is not intended to be an exhaustive list encompassing every duty and requirement of this position; your supervisor may assign other duties as considered necessary.