What are the responsibilities and job description for the Research Scientist, Level 1 (Center for Dementia Research) (210-2025-62) position at Research Foundation for Mental Hygiene, Inc.?
JOB DESCRIPTION:The position provides a rich multidisciplinary environment for postdoctoral training and more advanced career development. The candidate will receive a multidisciplinary training investment in performing multi-'omics expression profiling studies at the single population and subregional level relevant towards understanding the potential pathogenesis of selective neuronal vulnerability during the progression of dementia. The position available involves studies of cellular and animal models and postmortem human brain tissues to investigate vulnerable neuronal populations via single population RNA sequencing (RNA-seq), digital spatial profiling (DSP), and related validation strategies within the hippocampus, basal forebrain, and cortex.JOB DUTIES:Job requirements include microaspiration of pyramidal neurons and basal forebrain cholinergic neurons from mouse brain and postmortem human brain tissues via laser capture microdissection (LCM), preparing samples for RNA-seq, cryocutting frozen postmortem human and animal model brains for digital spatial profiling (DSP), and subsequent bioinformatic and pathway analyses of the resultant datasets. Additional technical experience with RNA amplification, siRNA knockdown delivery, surgical manipulations, ELISA, confocal microscopy, Western blotting, and real-time qPCR is strongly recommended.JOB QUALIFICATIONSMinimum Qualifications:Bachelor's degree and two years of professional research experience in an appropriate field or master's degree in an appropriate field may substitute for one year of the experience.Preferred Qualification:
- Ph.D. in Neuroscience/Molecular Cellular Neuroscience
- Experience with human neuroanatomy
- Experience with molecular and cellular neuroscience in mouse and/or postmortem human brain tissues
- Experience with laser capture microdissection
- Experience with RNA-sequencing
- Experience with digital spatial profiling
- Training in statistics/bioinformatics
- Previous work with miceBackground Investigation/Justice Center Review Requirements:Prospective appointees will be: 1) Checked against the Staff Exclusion List (SEL) maintained by the Justice Center for the Protection of People with Special Needs. Prospective employees whose names appear on the SEL as having been found responsible for serious or repeated acts of abuse or neglect will be barred from appointment. 2) Screened against the Statewide Central Register of Child Abuse and Maltreatment (SCR). Prospective employees whose names are indicated on the SCR may be barred from appointment.*The Research Foundation is a private not-for-profit corporation and is not an agency or instrumentality of the State of New York. Employees of the Research Foundation are not state employees, do not participate in any state retirement system, and do not receive state fringe benefits. Excellent Benefits Package. Affirmative Action/Equal Opportunity Employer - Disabled/Veteran, 41 CFR 60-741.5(a) and 41 CFR 60-300.5(a) compliant.Applications will only be accepted through website at: http://corporate.rfmh.org - Click on Employment Opportunities. Applications will be accepted only during the posting dates as listed at the top of the job announcement.Questions regarding this position please email: hrprocessing@nki.rfmh.org