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Senior Principal Scientist - Neurology and Ophthalmology Imaging

Regeneron
Tarrytown, NY Full Time
POSTED ON 10/17/2026
AVAILABLE BEFORE 2/14/2027

Senior Principal Scientist, Ophthalmology & Neurology

Clinical Imaging


Build our future together:

We are seeking a Senior Principal Scientist with a focus in Ophthalmology and Neurology to join our Clinical Imaging team. You will conceptualize, support, execute, and optimize complex imaging measures and biomarkers in early- to late-phase clinical trials. You will work closely with Regeneron clinical, preclinical and external partners, with emphasis on delivery of high-quality imaging data and development of innovative imaging-based biomarkers across imaging modalities and indications.


When & where:

Location: Tarrytown, NY United States


Discover your role:

  • Guide Regeneron clinical teams as imaging subject matter expert to ensure optimal design and execution of imaging biomarker strategy related to study endpoints, including development of protocols, imaging manuals, imaging charters and statistical analysis plans, and be the main clinical team collaborate with imaging Clinical Research Organizations, ensuring flawless conduct and data integrity of study's imaging components.
  • Collaborate closely with Research colleagues to develop and qualify imaging biomarkers with a view toward clinical translation.
  • Lead the development and execution of innovative joint image analyses projects, including novel imaging biomarker development, while collaborating closely with different departments and functions such as Regeneron Genetics Center, Imaging Sciences, Translational Medicine, Biostatistics and Data Management, etc.
  • Collaborate closely with external vendors, investigators and site personnel and Clinical operations teams to ensure the appropriate selection of Imaging equipment and parameters for image acquisition and pre- and on-study QC/calibration and standardization.
  • Oversee image analysis and interpretation of results and work closely with colleagues to oversee the development of study reports and publications as appropriate.
  • Support regulatory submission packages with the appropriate original content and documentation.

This role requires:

  • Demonstrated outstanding oral and written communication skills.
  • Work efficiently within a fast-paced, collaborative environment.
  • Come up with new and outstanding ideas that move solutions forward.
  • Possess a broad knowledge and perspective and are future oriented.
  • Desire to make a broader impact on developing medicines for patients with serious diseases.
  • A PhD in a relevant field, with 6 years of demonstrated ability in Ophthalmology and Neurology Clinical Imaging.
  • Extensive familiarity with ocular and neuro imaging modalities such as OCT, FA, CFP, MRI, PET etc.
  • A strong understanding of imaging file formats and analysis methods.
  • Demonstrated ability in the development and validation of imaging biomarkers.
  • Industry experience in creating and managing imaging protocols, manuals, and charters, and proficiency in statistical analysis plans related to imaging endpoints.


Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.


Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.


As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.


For jobs in Canada: this posting is for an existing position.


Salary Range (annually)

$150,500.00 - $245,500.00

Salary : $150,500 - $245,500

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