Principal IT Systems Engineer

Build Our Future Together

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Principal or Staff IT Systems Engineer to join our IOPS IT team, serving as a senior technical leader responsible for the reliability, uptime, availability, and performance of our server and infrastructure environments. In this role, you will combine hands-on engineering ownership with technical mentorship — maintaining GMP compliance, driving security and risk management initiatives, and setting standards for operational excellence — while collaborating with security, engineering, and cross-functional teams across the organization. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & Where

• Location: Troy, New York, United States
• Work model: Monday - Friday 8am - 4:30pm
  
  

Discover Your Role

• Proactively monitor and maintain Windows Server and virtualized environments, ensuring consistent performance, high availability, security, and resilience across network resources; conduct root cause analysis and implement corrective actions to prevent recurrence
• Design, deploy, and maintain endpoint security strategies including EDR and AV solutions; drive improvements in EDR and Lifecycle Management to strengthen risk management capabilities across IT and OT environments
• Maintain and update the IT Risk Register, tracking identified risks, mitigation efforts, and status; act as backup for Disaster Recovery planning and execution, maintaining continuity of risk management activities during critical events
• Strengthen monitoring coverage, alert quality, and system-health visibility as part of the IOPS performance, alerting, and observability strategy
• Partner with security teams to align IAM systems and infrastructure with organizational security policies and frameworks; implement and manage change control processes to uphold system integrity and GMP compliance
• Produce regular status reports on risk metrics, mitigation progress, EDR/LCM updates, and operational KPIs; develop and maintain documentation of processes, procedures, and best practices
• Provide technical leadership and mentorship to engineers across the team, setting standards for design, troubleshooting, and operational excellence; serve as SME and escalation point for complex technical issues
• Experience with SailPoint, CyberArk, Ivanti, and observability platforms such as Grafana, Nexthink, or Axonius preferred. Experience with cloud platforms including AWS and Oracle; familiarity with High Performance Computing (HPC) a plus
• Experience working in GMP environments and ensuring compliance with relevant standards preferred; knowledge of IT compliance guidelines including PIC/S, 21 CFR Part 11, Annex 11, and GAMP preferred
• Relevant certifications such as MCSE, VCP, CCNA, SailPoint, CyberArk, CISSP, CCSP, PMP, Security , CySA , or PenTest a plus
  
  

This Role Requires

• BA/BS in Computer Science or a related field
• Principal IT Systems Engineer: 8 years of relevant experience with data center technologies (VMware, NetApp, Dell EMC storage), backup solutions, and IT and Security operations
• Staff IT Systems Engineer: 10 ears of relevant experience with data center technologies (VMware, NetApp, Dell EMC storage), backup solutions, and IT and Security operations
  
  

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$92,200.00 - $176,000.00