Senior Research Associate/Associate Scientist, Therapeutic Translation

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures.

We are seeking a motivated and creative Senior Research Associate/Associate Scientist to join our Therapeutic Translation Team. In close collaboration with our bioinformatics, machine learning, and automation teams, you will lead efforts to discover, characterize, and engineer novel gene editing proteins. This includes developing robust high-throughput workflows in cell-based and biochemical systems. Your work will be foundational for expanding our gene editing toolbox and enabling new therapeutic opportunities.

The ideal candidate will have extensive experience with protein engineering, high throughput assay design and mammalian genome editing methods and workflows. This is an excellent opportunity to work cross-functionally with a diverse team of experts across machine learning, protein design, cell biology, and gene editing. 

Responsibilities:

• Working closely with bioinformatics, machine learning, and automation, lead cross-functional campaigns to discover, characterize, and engineer proteins for DNA manipulation.
• Design, execute, and automate robust cell-based and biochemical workflows for the characterization and engineering of novel gene editing tools. 
• Develop and validate assays to measure on- and off-target activity of novel gene editing systems using a combination of targeted and genome-wide analytical methods.
• Analyze data to inform critical go/no-go decisions, and clearly present conclusions and rationale to stakeholders across the organization.
• Stay up to date on the latest developments in gene editing technology.

Qualifications: 

• Bachelor's degree in molecular biology, biochemistry, or a related field with 4-8 years of relevant experience, or Master’s degree with 2-6 years of relevant experience; Title commensurate with experience.  
• Hands-on experience in protein engineering.  
• Hands-on experience with mammalian genome editing and mammalian cell culture.
• Expertise in high throughput screening (mammalian, microbial, and/or in vitro)
• Hands-on experience with NGS-based assays.  
• Hands-on experience with molecular cloning. 
• Proven track record of successfully delivering on ambitious research projects.
• Excellent communication skills to communicate data and project updates across teams with diverse technical backgrounds.  

Preferences (but not required):

• In-depth knowledge of DNA repair and methods to analyze DNA repair outcomes.
• Deep understanding of design and execution of NGS-based assays. 

What we offer at Profluent

• A high-growth opportunity with meaningful impact
• Competitive compensation package
• Health insurance (health/dental/vision)
• Generous paid time off (PTO) policy
• Commitment to physical and mental well-being
• More benefits and perks to be added!

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.