What are the responsibilities and job description for the Associate Director or Director of Clinical Science position at Prelude Therapeutics?
Company Description Prelude Therapeutics is a precision oncology company focused on developing innovative medicines for cancer indications with significant unmet need. Its pipeline includes highly selective KAT6A degraders and mutant-selective JAK2V617F JH2 inhibitors, offering novel approaches to validated targets with potential for meaningful patient impact. The company also applies deep expertise in targeted protein degradation to create next-generation degrader antibody conjugates (DACs) with novel payloads. Prelude is driven by a mission to expand the benefits of precision medicine to more people living with cancer and collaborates across disciplines to advance cutting-edge therapies.
Role Description The Associate Director or Director of Clinical Science is a remote, contracted position. This position is responsible for leading and executing clinical science activities across one or more oncology programs, including protocol development, clinical trial design, and interpretation of clinical and translational data. The role partners closely with Clinical Operations, Biostatistics, Regulatory Affairs, and Translational Research to ensure scientifically rigorous, patient-focused studies and high-quality study documents. Day-to-day responsibilities include authoring and reviewing clinical sections of regulatory submissions, supporting investigator and site interactions, overseeing data review and safety monitoring, and contributing to publications and presentations. The individual in this role also provides scientific leadership to cross-functional teams, supports strategic portfolio decisions, and helps drive the overall clinical development strategy for precision oncology assets.
Qualifications
- Clinical and medical expertise: Strong background in Medicine and Clinical Supervision, with experience overseeing clinical trials and patient safety in oncology or related therapeutic areas.
- Behavioral and psychological insight: Knowledge of Mental Health, Psychology, and Behavioral Health sufficient to understand patient-reported outcomes, quality-of-life measures, and holistic patient care considerations in clinical studies.
- Education and experience: Advanced degree (MSc, PhD, or PharmD) in a relevant scientific or medical discipline desirable; significant industry or academic experience in clinical development, ideally in oncology and precision medicine.
- Clinical development skills: Proven ability to design clinical trials, write protocols and clinical study reports, interpret complex clinical and biomarker data, and contribute to regulatory submissions.
- Cross-functional collaboration: Demonstrated experience working within multidisciplinary teams and partnering with Clinical Operations, Biostatistics, Regulatory Affairs, and Translational/Discovery research groups.
- Communication and leadership: Excellent written and verbal communication skills, including the ability to present scientific data clearly; capacity to provide scientific leadership and influence decision-making across levels.
- Regulatory and compliance awareness: Familiarity with ICH/GCP guidelines, ethical research principles, and regulatory requirements for oncology clinical trials.
- Preferred qualifications: Hematology drug development experience.