What are the responsibilities and job description for the Senior Medical Science Liaison - Movement Disorders position at Praxis Precision Medicines, Inc.?
Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.
The Opportunity
Praxis is seeking a field-based Senior Medical Science Liaison (Senior MSL) to support Medical Affairs activities for ulixacaltimide during prelaunch and potential launch. This role is focused on building trusted scientific partnerships, delivering high-quality scientific exchange, and generating actionable insights to inform medical strategy and ensure clinical readiness. You will provide coaching, guidance, and peer leadership to other MSLs while also maintaining strategic engagement with key investigators, movement disorder specialists, and other neurology stakeholders.
This individual will play a critical role in translating medical strategy into field execution, ensuring high-quality scientific exchange, and driving clinical and account readiness in advance of and following potential approval. The role requires strategic thinking and field engagement, serving as a field-based scientific leader and trusted resource to the broader MSL team.
Given the significant unmet need in essential tremor and the opportunity to introduce a novel therapeutic option, this role will help shape disease education, stakeholder engagement, and the evolving treatment paradigm across both academic and community neurology settings.
Success in this role requires strong clinical credibility, excellent communication skills, strategic thinking, and comfort operating autonomously in a fast-paced environment.
Primary Responsibilities
Team Leadership & Development
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles.
Annualized Base Salary: $190,000 USD - $220,000 USD
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com.
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
The Opportunity
Praxis is seeking a field-based Senior Medical Science Liaison (Senior MSL) to support Medical Affairs activities for ulixacaltimide during prelaunch and potential launch. This role is focused on building trusted scientific partnerships, delivering high-quality scientific exchange, and generating actionable insights to inform medical strategy and ensure clinical readiness. You will provide coaching, guidance, and peer leadership to other MSLs while also maintaining strategic engagement with key investigators, movement disorder specialists, and other neurology stakeholders.
This individual will play a critical role in translating medical strategy into field execution, ensuring high-quality scientific exchange, and driving clinical and account readiness in advance of and following potential approval. The role requires strategic thinking and field engagement, serving as a field-based scientific leader and trusted resource to the broader MSL team.
Given the significant unmet need in essential tremor and the opportunity to introduce a novel therapeutic option, this role will help shape disease education, stakeholder engagement, and the evolving treatment paradigm across both academic and community neurology settings.
Success in this role requires strong clinical credibility, excellent communication skills, strategic thinking, and comfort operating autonomously in a fast-paced environment.
Primary Responsibilities
Team Leadership & Development
- Recruit, onboard, and develop a high-performing team of MSLs, including both senior and early-career talent
- Operate within a player/coach model, providing direct oversight, coaching, and field engagement alongside MSLs
- Establish clear expectations for scientific exchange quality, insight generation, and stakeholder engagement
- Conduct regular field travel and joint visits with MSLs to observe, coach, and elevate performance
- Foster a culture of ownership, accountability, and continuous development across the team
- Foster a high-performing, collaborative team culture grounded in scientific excellence, accountability, and continuous development
- Translate medical strategy into a clear, executable field plan aligned with pre-launch and launch priorities
- Oversee territory planning, KOL identification, and stakeholder engagement strategies across regions
- Ensure consistent, high-quality scientific exchange across the team, including disease state education and product data communication
- Support clinical and account readiness efforts, including site preparedness, patient identification, and integration into clinical practice
- Monitor field activity and adapt strategy based on evolving insights and market dynamics
- Lead territory alignment and resource deployment strategies to ensure optimal coverage of key accounts and stakeholders
- Support the evolution of field medical strategy across the product lifecycle, from pre-launch readiness through post-launch adoption and expansion
- Maintain direct relationships with key national and regional KOLs, investigators, and thought leaders
- Lead high-impact scientific engagements, including advisory boards, congress interactions, and complex clinical discussions
- Serve as a scientific leader within the organization, ensuring credibility and consistency in external interactions
- Support the identification and development of emerging influencers and strategic partnerships
- Oversee the collection, synthesis, and communication of field insights to inform medical and cross-functional strategy
- Partner closely with Clinical Development, Commercial, and Market Access to ensure alignment and effective execution
- Translate field insights into actionable recommendations that shape launch strategy, evidence generation, and stakeholder engagement
- Contribute to the development of medical materials, training, and strategic initiatives as needed
- Represent the voice of the external medical community by translating field insights into strategic recommendations that inform medical and cross-functional decision-making
- Ensure all field medical activities are conducted in compliance with regulatory requirements, company policies, and SOPs
- Partner with internal teams to support training, onboarding, and field effectiveness initiatives
- Establish and track key performance indicators for field medical impact and execution
- Support planning and execution of congresses, advisory boards, and other key medical activities
- Establish and monitor key performance indicators (KPIs) to evaluate MSL effectiveness, scientific engagement quality, and overall field impact
- Contribute to field medical planning, including budget, resource allocation, and operational prioritization
- Partner with internal teams to develop and implement onboarding and ongoing training programs to ensure consistent field capability and scientific rigor
- Advanced clinical or scientific degree (PharmD, PhD, MD, NP, PA, or RN)
- Experience in medical affairs, clinical research, clinical care, or field-based roles within biotech/pharma
- Demonstrated ability to interpret, communicate, and translate complex scientific and clinical data into clear, actionable insights for diverse stakeholders
- Strong ownership mindset with the ability to operate independently, navigate ambiguity, and drive impact in a dynamic pre-launch/launch environment
- Proven ability to build and maintain trusted relationships with healthcare professionals, including investigators and key opinion leaders
- Experience gathering, synthesizing, and translating field insights into actionable recommendations for cross-functional teams
- Ability to manage multiple priorities with strong organizational skills, attention to detail, and consistent follow-through
- Willingness and ability to travel extensively (~60–80%) in a field-based role
- Demonstrated experience leading, coaching, and developing field-based teams, with the ability to drive performance and accountability
- Proven ability to translate medical strategy into effective field execution and operational plans
- Experience influencing cross-functional stakeholders and aligning teams in a matrixed environment
- Experience in neurology, CNS disorders or movement disorders is preferred
- Experience within market access/payor landscape is preferred
- Demonstrated ability to rapidly develop expertise in new therapeutic areas and apply insights to field strategy
- Candidates with prior field-based experience and a demonstrated track record of independently driving scientific engagement, shaping clinical perspectives, and contributing to successful pre-launch and launch activities will be considered at a higher level
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles.
Annualized Base Salary: $190,000 USD - $220,000 USD
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com.
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
Salary : $190,000 - $220,000