Senior Software Engineer, Full Stack

Senior Software Engineer, Data Pipelines

About Perimeter

Perimeter builds for resilience in an era of accelerating biological risk. Our end-to-end biosecurity infrastructure platform spans detection, characterization, forecasting, and response — powered by frontier AI and deployed across airports, hospitals, wastewater systems, and critical infrastructure worldwide. Perimeter's infrastructure maps the biological landscape, transforming biological data into biointelligence, enabling decisive response as soon as a threat emerges.

https://www.perimeter.bio/

About The Role

We are seeking a Staff Full-Stack Software Engineer to join our BUILD team. This role is ideal for someone who thrives in cross-disciplinary environments and is excited to build production software that directly supports biosecurity, epidemiology, and biological data workflows. We are looking for an engineer who is not only a technical expert but also a forward-thinker who embraces AI-augmented development and maintains a 'deploy-with-confidence' culture through rigorous CI/CD and automated testing

You will work across the stack—from backend services and data pipelines to user-facing web applications—building reliable, scalable systems that turn complex biological data into actionable insights.

Responsibilities

• Develop high-performance full-stack applications that translate complex biological data and operational needs into intuitive software using Python and modern JavaScript frameworks
• Champion an AI-first mindset, leveraging generative AI tools and LLM-based assistants to accelerate feature development, optimize code quality, and automate routine engineering tasks
• Collaborate with cross-functional domain experts to architect and operate on biological datasets (genomic, diagnostic, or epidemiological), ensuring that surveillance workflows maintain high standards for data integrity, provenance, and security.
• Influence the technical roadmap and long-term evolution of the Biosecurity platform, identifying and mitigating technical debt and architectural bottlenecks before they impact delivery.
• Design and implement robust CI/CD pipelines where automated unit, integration, and security testing are treated as mandatory gates for every code deployment.
• Drive engineering excellence by leading technical design reviews and providing critical feedback on software modularity, while upholding rigorous standards for documentation, observability, and long-term maintainability
• Support production systems by monitoring performance, troubleshooting issues, and continuously improving reliability, including on-call support and triage in off hours

Minimum Requirements

• 6-8 years of professional software engineering experience, with significant full-stack development work, including ownership of complex systems and cross-team technical initiatives.
• Strong proficiency in Python for backend development (our primary programming language).
• Experience building and consuming APIs (REST and/or GraphQL).
• Experience developing modern web frontends using JavaScript/TypeScript and frameworks such as React.
• Demonstrated ability to integrate AI-assisted development tools (e.g., GitHub Copilot, Cursor, or similar) into daily workflows to increase productivity and code reliability
• Proven experience collaborating domain experts (scientific, operations, product, etc) to translate complex biological data (genomic, diagnostic, or epidemiological) into robust software solutions and actionable insights
• Solid grounding in software engineering fundamentals: data structures, system design, version control, and modern CI/CD patterns for automated testing and deployment

Preferred Capabilities and Experience

• Prior experience in bioinformatics, computational biology, public health, or a related domain.
• Familiarity with cloud infrastructure (e.g., AWS) and containerized environments (Docker, Kubernetes).
• Experience with data pipelines, workflow orchestration, or analytics platforms.
• Exposure to regulated or sensitive-data environments (e.g., HIPAA, public health data).
• Demonstrate high levels of ownership and independent execution
• Comfort working in fast-moving, ambiguous problem spaces where requirements evolve
• Flexibility and willingness to work on the highest priority needs of the business

You Should Apply If You...

• Are passionate about working on a mission that matters & has real global impact
• Are a self-starter who thrives in dynamic, fast-moving environments and gets energized by ambiguity rather than slowed down by it
• Want to be part of building something from the ground up — we're a small, scrappy team, and we're looking for people who are comfortable operating without a full playbook but are equally excited about helping us build the processes and foundations that will carry us forward as we grow