Chemistry Contractor

Why join us?

Parabilis Medicines is a highly distinctive young biopharmaceutical company whose intention is to grow over time into the ranks of major therapeutics companies. Our foundational platform of Helicon™ therapeutics are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

An important distinctive element of Parabilis is our lead program FOG-001, the company's first-in-class TCF-blocking β-catenin inhibitor. This compound is approximately 18 months and ~50 patients into our early development program for patients with advanced solid tumors, most importantly colorectal cancer. There are few products in the ecosystem with the medical and economic potential of FOG-001. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis Medicines is headquartered in Cambridge, Mass.

What's the opportunity?

We are seeking a skilled and highly motivated chemist to join our dynamic, interdisciplinary drug discovery team. In this lab-based role, you will synthesize Helicons (stapled peptides) that target drivers of severe disease that remain out of reach of current therapeutics. Ideal candidates will be passionate and energetic, with significant hands-on chemistry lab experience.

Specific responsibilities include:

• Synthesis of stapled peptides (Helicons), using solid phase synthesis to help drive hit-to-lead advancement for a variety of challenging targets.
• Use synthetic chemistry (solid-phase and solution-phase) to derivatize Helicons with various chemical modifications.
• Use solution-phase chemistry to prepare small molecule building blocks.
• Use UPLC- and LC-MS-based methods to monitor synthesis purity and biproducts.
• Accurately record, analyze, and present data to team members and company
• Act as a dynamic and collaborative teammate with other members of our interdisciplinary research group.

What you'll need to be successful:

• BS or MS in chemistry or related field is required, with 1-3 years of industry experience related to synthetic organic chemistry, synthetic methodology development (organic or organometallic), or process chemistry.
• Significant laboratory experience, including proficiency with fundamental chemistry lab methods, is required.
• Strong organic chemistry knowledge and experience with liquid chromatography-mass spectrometry instrumentation.
• Creativity, resourcefulness, and an ability to adhere to deadlines and commitments.
• An interest and desire to learn more about the drug discovery and development process.
• Excellent written and oral communication skills, and a personality of risk-taking, positivity, leadership, adaptability, adventurousness, and excitement to build a pioneering company and work in a dynamic, goal- and performance-oriented team environment.
• Able to work on-site and attend in-person meetings

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We're inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We're All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com