Demo

Manager/Sr. Manager, Human Resources

Oruka Therapeutics
Menlo Park, CA Full Time
POSTED ON 7/9/2026
AVAILABLE BEFORE 1/4/2027
About Us:

Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’s mission is to offer patients suffering from chronic skin diseases like plaque psoriasis the greatest possible freedom from their condition by achieving high rates of complete disease clearance with dosing as infrequently as once or twice per year. Oruka is advancing a proprietary portfolio of potentially best-in-class antibodies that were engineered by Paragon Therapeutics and target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. For more information, visit www.orukatx.com

As we build our core team, we're seeking top talent in different functional areas who are not just looking for a job, but an opportunity to be part of something bigger. Someone who is passionate about making a difference and eager to contribute to establishing an engaged, inclusive, and positive company culture.

Manager/Sr. Manager, Human Resources

Location: Hybrid - Menlo Park, CA (3 days onsite/week)

Position Summary

Reporting to the Senior Director, Human Resources, the Manager/Sr. Manager, Human Resources will serve as a trusted HR generalist who supports the day-to-day execution of key HR programs and operations. This hands-on role partners closely with the Senior Director to deliver operational excellence across the employee lifecycle, including recruiting support, onboarding, HR operations, benefits administration, leave management, compliance, performance management administration, and employee engagement.

The ideal candidate is an organized, collaborative HR professional who enjoys working in a growing organization, exercises sound judgment, and is committed to providing outstanding service to employees and managers while continuously improving HR processes and programs.

Key Responsibilities

Recruiting & Onboarding

  • Partner with the Talent Acquisition team and hiring managers to coordinate recruiting activities, interview scheduling, offer preparation, and other aspects of the hiring process.
  • Coordinate new hire onboarding and orientation to ensure a seamless and engaging employee experience.
  • Serve as a primary point of contact for new hires during the onboarding process.
  • Maintain job descriptions and applicant tracking system information in partnership with Talent Acquisition.
  • Prepare recruiting reports and hiring metrics as needed.

HR Operations

  • Serve as a resource for employees by responding to routine HR-related questions and directing more complex matters to the Senior Director, Human Resources as appropriate.
  • Support the Senior Director and managers in the consistent administration and communication of HR policies, programs, and processes.
  • Coordinate performance management activities, including review cycles, goal-setting processes, communications, and documentation.
  • Maintain HRIS data integrity and prepare reports, metrics, and analytics as needed.
  • Administer employee lifecycle transactions, including hires, promotions, transfers, status changes, and separations.
  • Maintain personnel files and HR documentation in compliance with company policies and applicable regulations.
  • Coordinate HR compliance activities, including I-9 administration, personnel record audits, required postings, recordkeeping, and support for policy updates.
  • Assist with planning and executing employee engagement initiatives, recognition programs, learning opportunities, and company events.
  • Identify opportunities to improve HR processes, workflows, and employee experience through continuous process improvement.

Benefits & Leave Administration

  • Coordinate benefits administration in partnership with the company’s PEO and benefit providers.
  • Serve as the primary internal contact for employee benefits questions and support annual open enrollment activities.
  • Coordinate leave of absence administration, including FMLA, ADA, parental leave, disability, and applicable state and local leave programs.
  • Track leave requests, documentation, eligibility, and return-to-work activities while partnering with the PEO, payroll, employees, and managers to ensure accurate administration.
  • Support compliance with applicable federal, state, and local employment laws related to benefits and leave administration.

Qualifications

  • Bachelor’s degree required.
  • 5 years of progressive Human Resources experience, preferably as an HR Generalist or HR Operations professional in a biotech, life sciences, or other fast-paced environment.
  • Experience supporting a high-growth startup or publicly traded company is preferred.
  • Working knowledge of federal and state employment laws, including FLSA, FMLA, ADA, and related regulations.
  • Experience supporting benefits administration, leave management, HRIS administration, onboarding, and employee lifecycle processes.
  • Strong organizational and project management skills with the ability to manage multiple priorities and deadlines.
  • Excellent interpersonal, written, and verbal communication skills and the ability to handle confidential information with discretion.
  • Strong customer service orientation with the ability to build effective working relationships across all levels of the organization.
  • Proficiency with Microsoft Office and HRIS platforms; experience working with a PEO and applicant tracking systems is preferred.
  • Comfortable working in a dynamic, high-growth environment where priorities evolve quickly.

Compensation

An appropriate compensation package will include a competitive base salary, equity, and performance-based bonus opportunity.

The anticipated salary range for Manager level is $146,000-$161,000 and Sr. Manager level is $161,000 - $187,000, with final compensation determined based on experience, qualifications, and other job-related factors.

Salary Range For the Role: $146,000 USD - $187,000 USD

What We Offer:

  • A chance to be part of a vibrant startup culture where your work can directly impact bringing new medicines to patients.
  • Competitive salary and benefits package.
  • A supportive and inclusive team environment where everyone is encouraged to bring their authentic selves to work.
  • Opportunities for professional growth and development.

Salary : $146,000 - $161,000

If your compensation planning software is too rigid to deploy winning incentive strategies, it’s time to find an adaptable solution. Compensation Planning
Enhance your organization's compensation strategy with salary data sets that HR and team managers can use to pay your staff right. Surveys & Data Sets

What is the career path for a Manager/Sr. Manager, Human Resources?

Sign up to receive alerts about other jobs on the Manager/Sr. Manager, Human Resources career path by checking the boxes next to the positions that interest you.
Income Estimation: 
$114,907 - $150,919
Income Estimation: 
$156,288 - $210,152
Income Estimation: 
$132,976 - $201,974
Employees: Get a Salary Increase
View Core, Job Family, and Industry Job Skills and Competency Data for more than 15,000 Job Titles Skills Library

Job openings at Oruka Therapeutics

  • Oruka Therapeutics Waltham, MA
  • About Us: Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’... more
  • 14 Days Ago

  • Oruka Therapeutics Waltham, MA
  • About Us: Oruka Therapeutics (Nasdaq: ORKA) is developing novel biologics designed to set a new standard for the treatment of chronic skin diseases. Oruka’... more
  • 6 Days Ago


Not the job you're looking for? Here are some other Manager/Sr. Manager, Human Resources jobs in the Menlo Park, CA area that may be a better fit.

  • Supermicro San Jose, CA
  • Job Req ID: 28455 About Supermicro Supermicro® is a Top Tier provider of advanced server, storage, and networking solutions for Data Center, Cloud Computin... more
  • 14 Days Ago

  • Super Micro Computer Spain, S.L. San Jose, CA
  • Apply now » Date: May 23, 2026 Location: San Jose, California, United States Company: Super Micro Computer Job Req ID: 28455 About Supermicro Supermicro® i... more
  • 6 Days Ago

AI Assistant is available now!

Feel free to start your new journey!