Demo

Director/Senior Director, Project Management

OnKure Therapeutics
Boulder, CO Full Time
POSTED ON 5/29/2026
AVAILABLE BEFORE 6/27/2026
OnKure is looking for an experienced project manager to join our team. Collaborating closely with Research & Development, CMC, and Clinical colleagues, the Director (or Senior Director, dependent on experience), Project Management will serve as the cross-functional team lead responsible for project management of an OnKure development program.

Job Responsibilities: 

  • Manage at least one asset-specific project, working vertically, horizontally, and cross-functionally to achieve goals and set realistic timelines
  • Serve as product development team lead
  • Lead and coordinate project team meetings, ensuring alignment and communication between working groups
  • Establish and maintain project timelines, coordinating with appropriate Discovery, CMC, Legal, Quality, Development, Regulatory, Finance, and Business Development stakeholders
  • Ensure project status, team activities, and decisions made are properly communicated, documented, and archived
  • Regularly communicate project updates to Executive Leadership
  • Proactively identify project risks, preparing plans for mitigation and contingencies
  • Manage cross-functional resources, timelines, and budget to ensure success
  • Provide project management for business development projects and academic collaborations
  • Build and maintain relationships with external partners, CROs, academic collaborators, and KOLs as needed to ensure goals and timelines are met
  • Demonstrate an ability to gain a technical working knowledge of the activities relevant to specific project domains
  • Collaborate with project management team to identify process improvements and ensure consistency across programs

Preferred Experience and Qualifications: 

  • BS/MS/PhD or equivalent in chemistry, biology, or a related discipline
  • 10 years’ experience project management in the biotech or pharmaceutical industry, with 5 years of oncology and/or rare disease project management experience preferred
  • Senior Director:12 years of experience
  • PMP Certification or Project Management training from an accredited program preferred
  • Demonstrated ability to communicate scientific and technical concepts to a broad audience
  • Demonstrated ability to implement structure on a cross-functional team to increase team efficiency
  • Strong communication skills, with a track record of leading cross-functional teams
  • Detail oriented with strong organizational skills
  • A desire to continue to learn and to jump in where needed at a small, growing organization

About OnKure

We are a clinical-stage biopharmaceutical company focused on discovering and developing precision medicines that target biologically validated drivers of diseases underserved by available therapies. Using a structure- and computational chemistry-driven drug design platform, we are committed to improving clinical outcomes for patients by building a robust pipeline of small-molecule drugs designed to selectively target specific mutations thought to be key drivers of cancer and vascular anomalies.

To attract the very best talent, OnKure offers a generous compensation and benefits package that includes competitive pay, performance-based bonus opportunities, stock options, insurance coverage (health, dental, life, and disability) for full-time employees, self-managed paid time off, and a 401(k) plan with company match. Candidates who live in or are willing to relocate to the Boulder, CO area are preferred.

The annual compensation range for this role, based on experience, is $200,000 - $275,000.

OnKure is an equal opportunity employer and welcomes all job applicants. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, protected veteran status, disability, or any other protected factors.

Salary : $200,000 - $275,000

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