Senior IT Systems Engineer

Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist (CERAN) currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER /HER2- metastatic breast cancer. Our follow-on product candidate, OP-3136, is a potent KAT6 inhibitor with best-in-class potential.

Our scientific breakthroughs are accelerated through the ways in which we fearlessly support, motivate, and challenge one another. At Olema, we know that when we put people first, our work becomes second to none. If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for our patients, for your career, for what’s beyond .

You can view our latest corporate deck and other presentations here .

About the Role >>> Senior IT Systems Engineer

As the Senior IT Systems Engineer reporting to the Senior Director, IT Infrastructure and Operations, you will manage, maintain, and optimize the core infrastructure, applications, and services that Olema relies on to securely and efficiently scale our business. This role encompasses system administration, operational support, and hands-on work with both on-prem and cloud-based infrastructure. The Senior IT Systems Engineer will also contribute to security, compliance, and automation initiatives, while mentoring junior staff and serving as a subject matter expert (SME) for critical IT systems.

This role is based out of our San Francisco office.

Your work will primarily encompass:

• Provide daily support for enterprise solutions, including troubleshooting, maintenance, and performance monitoring
• Manage cloud system across multiple cloud platform environments
• Perform maintenance and problem solving with respect to on-premises and cloud-based infrastructure
• Complete scheduled maintenance and system hardening activities aligned with security requirements
• Manage backup operations, disaster recovery planning, and periodic Disaster Recovery testing
• Lead small-to-medium IT projects from planning through execution, including requirements gathering, stakeholder communication, and delivery of technical solutions
• Collaborate with project teams to implement IT initiatives and deploy new technology solutions
• Maintain and update system documentation, including configuration, changes, and technical procedures
• Maintain accuracy of the Configuration Management Database (CMDB) for enterprise systems
• Coordinate with MSP service teams on patching and vulnerability remediation efforts to strengthen the overall security posture
• Participate in periodic system access reviews, compliance audits, and other IT governance activities
• Act as a subject matter expert (SME) and escalation point for incident resolution
• Coordinate with the Help Desk to analyze application issue trends and drive permanent fixes
• Enable knowledge sharing by documenting processes and providing guidance to IT team members
• Mentor junior staff to develop technical skills and strengthen the IT team
• Identify opportunities for automation, streamline IT processes, and eliminate manual work to enhance efficiency
• Communicate clearly with diverse stakeholders (executives, scientists, staff) and tailor explanations of technical issues to the appropriate audience
  
  

Ideal Candidate Profile >>>

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role.

Knowledge:

• Bachelor's degree in computer science or related required
• Technical expertise in Okta and Microsoft 365 administration, MDM (JAMF & Intune), SAML integrations, SaaS management, Networking (Meraki), Zoom, Python scripting, Mac/PC, GCP, AWS, Office 365, Arctic Wolf, Netskope and CrowdStrike
• Comprehensive knowledge and hands-on experience in implementing, managing, and securing networks (DHCP, DNS, SSID, LAN, WAN) with strong problem-solving skills
• Experience in supporting Mac, PC, and Chrome hardware, as well as mobile devices (iPhone, iPad, and Android)
• Proven experience managing IT projects, balancing competing deadlines, and delivering results in a fast-paced environment
• Certifications in Information Security and IT disciplines such as OKTA (Admin & workflow, Certification OCA), MCSE, Netskope (Certification NCCSA), CISSP, CEH, Network , etc. preferred
  
  

Experience:

• A minimum of 7 years of hands-on IT systems engineer/administration experience
• Experience working in a fast-growing biotechnology company and supporting users in life sciences or biopharma environment is preferred
• Direct experience with SaaS products, solutions, or ecosystems required
• Driving results and outcomes while solving complex problems
• Hands-on, resolving daily tickets and projects as needed
• Detail-oriented and customer-focused, with a strong ability to deliver results aligned with data and business needs
  
  

Attributes:

• Strong communication and interpersonal skills with the ability to adapt technical explanations for different audiences
• Demonstrated ability to build trust, foster collaboration, and drive adoption of IT solutions across both technical teams and business stakeholders
• Demonstrated excellent written and oral communication skills, as well as thoughtful listening skills, to facilitate interaction with all levels of an organization
• Ability to analyze complex business problems and evaluate solutions
• Superior organization, planning, and project management skills
  
  

The base pay range for this position is expected to be $150,000 - $175,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.

Important Information >>>

We provide equal opportunity to all employees and applicants for employment and believe that great ideas and discoveries come from a mix of expertise, background, and experience. Olema is building a culture where the value of difference is celebrated.

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants.

Please note: Olema doesn’t accept agency resumes and is not responsible for any fees related to unsolicited resumes. Thank you.

Fraud Alert: We are aware of employment scams where individuals pose as representatives of Olema Oncology and make false use of our company name to defraud job seekers. To protect yourself, please note that Olema’s official email addresses end in @olema.com. Our official corporate website is olema.com; our careers page is olema.com/careers; our LinkedIn page is linkedin.com/company/olema-oncology . Please visit these links for official information from Olema. Communication from any other variant is fraudulent. Olema does not conduct interviews via text message/messaging platforms, will not ask you to download anything as part of your interview, will never request any form of payment, provide upfront payments of any kind, and does not make job offers without an in-person interview.