Principal Scientist I/II, Molecular Pathology

📍 Cambridge, MA (Onsite)About the RoleThe Molecular Pathology team within Oncology Translational Research at Biomedical Research (BR) is seeking a highly motivated Principal Scientist to develop, validate, and scale novel approaches to characterize protein features of drug targets. This onsite role in Cambridge, MA offers the opportunity to work in a highly collaborative laboratory environment alongside cross-functional teams.In this role, you will lead efforts to understand how protein features—including proteoforms, localization, conformation, and interactions—impact response and resistance in cancer. You will partner closely with target validation, drug discovery, and translational teams to generate insights from patient samples and translate findings to preclinical models.Your work will directly contribute to translational strategies across the drug development continuum, from target characterization through biomarker development.Key ResponsibilitiesContribute to and help shape proteomics strategy and technology platforms in a translational research environmentIdentify and develop novel scientific and methodological opportunities based on literature and internal insightsDesign, develop, and scale methods to characterize:ProteoformsProtein localizationConformationProtein–protein interactionsApply approaches to patient-derived samples and define translational relevance in preclinical modelsCollaborate across matrixed teams spanning Oncology Research, Discovery, and Translational ScienceLead or contribute to cross-functional initiatives supporting target understanding and biomarker developmentEssential RequirementsPhD in Oncology, Cell Biology, Biochemistry, Molecular Biology, or a related disciplineLeveling criteria (dual posting):Principal Scientist I: 3 years of postdoctoral trainingPrincipal Scientist II: Postdoctoral training 3 years of industry experienceProven ability to generate data that influences scientific and technical decision-makingExperience with:In vitro and in vivo modelsClinical or post-mortem patient samplesStrong expertise in protein characterization techniques, including:Western blottingELISAFACSHigh-content imagingMicroscopy-based approachesExperience with methods to probe, label, and enrich proteoforms or related protein featuresStrong critical thinking, communication, and collaboration skillsCuriosity and adaptability to explore emerging technologies and scientific innovationsDesirable QualificationsExperience with mass spectrometry and proteomics workflows (data generation and interpretation)Data analysis and visualization skills (e.g., Spotfire, R)Novartis Compensation and Benefit Summary: The salary for this position is expected to range between $108,500.00 - 201,500.00 USD Annual per year.The final salary offered is determined based on factors like, but not limited to, relevant skills andexperience, and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.Your compensation will include a performance-based cash incentive and, depending on the level of therole, eligibility to be considered for annual equity awards.US-based eligible employees will receive a comprehensive benefits package that includes health, life anddisability benefits, a 401(k) with company contribution and match, and a variety of other benefits. Inaddition, employees are eligible for a generous time off package including vacation, personal days,holidays and other leaves.