What are the responsibilities and job description for the Senior Clinical Trial Manager position at Neurocentria, Inc.?
About Neurocentria
Neurocentria is a clinical-stage neuroscience company developing magnesium L-threonate (MgT) as a precision intervention for cognitive health and neurological disorders. Our lead compound uniquely elevates brain magnesium by crossing the blood–brain barrier — a mechanism of action originating from 20 years of research. Two completed human trials have demonstrated significant cognitive effects, and our current clinical program represents a pivotal scientific and commercial milestone for the company.
The Role
We are looking for a Senior Clinical Trial Manager to serve as the primary operational lead for two concurrent decentralized Phase 2 clinical trials in neurology and cognitive health. Both studies are fully decentralized — no in-person clinic visits — with all assessments conducted remotely or through local laboratory networks.
This is a senior individual contributor role within a lean internal team. You will work directly with the Principal Investigator and Head of Clinical Operations, owning day-to-day CRO performance, vendor relationships, budgets, timelines, and regulatory compliance from study startup through database lock.
Responsibilities
Please submit a current CV and a brief cover letter (one page maximum)
Neurocentria is a clinical-stage neuroscience company developing magnesium L-threonate (MgT) as a precision intervention for cognitive health and neurological disorders. Our lead compound uniquely elevates brain magnesium by crossing the blood–brain barrier — a mechanism of action originating from 20 years of research. Two completed human trials have demonstrated significant cognitive effects, and our current clinical program represents a pivotal scientific and commercial milestone for the company.
The Role
We are looking for a Senior Clinical Trial Manager to serve as the primary operational lead for two concurrent decentralized Phase 2 clinical trials in neurology and cognitive health. Both studies are fully decentralized — no in-person clinic visits — with all assessments conducted remotely or through local laboratory networks.
This is a senior individual contributor role within a lean internal team. You will work directly with the Principal Investigator and Head of Clinical Operations, owning day-to-day CRO performance, vendor relationships, budgets, timelines, and regulatory compliance from study startup through database lock.
Responsibilities
- Serve as the primary sponsor-side point of contact for the full-service DCT CRO, monitoring performance weekly against contractual deliverables across both trials
- Identify and escalate operational risks proactively — enrollment trends, screen failure rates, dropout signals, data quality issues, and timeline slippage — before they become milestone failures
- Lead study startup activities including CRO RFP coordination, proposal evaluation, and contract review; confirm all regulatory gates are cleared before enrollment opens
- Maintain Trial Master File completeness and audit readiness; track and triage protocol deviations and SAE reporting timelines
- Manage trial budgets and CRO invoicing across both studies; evaluate change order requests and prepare recommendations for approval
- Support IND amendments, IRB submissions, and regulatory authority interactions as directed by the Principal Investigator
- Bachelor’s degree in life sciences, clinical research, nursing, or a related field; advanced degree preferred (MS, MPH, PharmD)
- Minimum 8 years of clinical trial operations experience in the pharmaceutical or biotechnology industry
- Demonstrated experience as primary operational lead on at least one Phase 2 or later IND-quality clinical trial, from startup through database lock
- Minimum 3 years of direct CRO oversight in a sponsor-side role, including vendor selection, performance management, and change order negotiation
- Experience with decentralized clinical trials (DCT) or hybrid trial models, including remote subject management, electronic consent, and digital endpoint or ePRO platforms
- Strong working knowledge of ICH GCP guidelines (E6 R2/R3), 21 CFR 312, and eTMF standards
- Proficiency with EDC systems (REDCap, Medidata Rave, or equivalent)
- CNS, neurology, or cognitive health therapeutic area experience strongly preferred
- Experience with blood-based biomarker logistics in a clinical trial setting
- Familiarity with digital cognitive assessment platforms or tablet-administered endpoint technology
- Experience with patient recruitment in biomarker-enriched or specialty populations
- CDISC SDTM familiarity and experience with datasets for regulatory submissions
- ACRP or SOCRA certification (CCRC, CCRP, CCRA) is a plus
- Primary operational ownership of two concurrent clinical programs at a pivotal stage of company development
- Direct daily collaboration with the Principal Investigator and Head of Clinical Operations in a lean, science-driven team
- Salary range: $160,000 – $190,000 (commensurate with experience and qualifications)
- 401(k) with above-market company contribution
- Comprehensive medical, dental, vision, and life insurance (100% employee premium coverage; 50% dependent premium coverage)
- Paid time off including vacation, floating holiday, sick leave, and annual winter week shutdown
Please submit a current CV and a brief cover letter (one page maximum)
Salary : $160,000 - $190,000